产品名称
(+)-荷包牡丹碱, 98%
SMILES string
[H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]4([H])N(C)CCc5cc6OCOc6cc45
InChI
1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
InChI key
IYGYMKDQCDOMRE-ZWKOTPCHSA-N
assay
98%
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Biochem/physiol Actions
(+)-荷包牡丹碱是一种 GABAA 受体拮抗剂。
法规信息
新产品
此项目有
Kevin W McCairn et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(2), 697-708 (2013-01-11)
Motor tics, a cardinal symptom of Tourette syndrome (TS), are hypothesized to arise from abnormalities within cerebro-basal ganglia circuits. Yet noninvasive neuroimaging of TS has previously identified robust activation in the cerebellum. To date, electrophysiological properties of cerebellar activation and
G Palazzolo et al.
Scientific reports, 7(1), 8499-8499 (2017-08-19)
The need for in vitro models that mimic the human brain to replace animal testing and allow high-throughput screening has driven scientists to develop new tools that reproduce tissue-like features on a chip. Three-dimensional (3D) in vitro cultures are emerging
Ning Gu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(19), 8276-8287 (2013-05-10)
Increasing evidence suggests that synchronization between brain regions is essential for information exchange and memory processes. However, it remains incompletely known which synaptic mechanisms contribute to the process of synchronization. Here, we investigated whether NMDA receptor-mediated synaptic plasticity was an
Yu-Cheng Ho et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(18), 7825-7836 (2013-05-03)
Neuropathic pain, a chronic pain due to neuronal lesion, remains unaltered even after the injury-induced spinal afferent discharges have declined, suggesting an involvement of supraspinal dysfunction. The midbrain ventrolateral periaqueductal gray (vlPAG) is known to be a crucial supraspinal region
Giuseppina Martella et al.
Brain : a journal of neurology, 132(Pt 9), 2336-2349 (2009-07-31)
DYT1 dystonia is a severe form of inherited dystonia, characterized by involuntary twisting movements and abnormal postures. It is linked to a deletion in the dyt1 gene, resulting in a mutated form of the protein torsinA. The penetrance for dystonia
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