291552
6-甲氧基-1,2,3,4-四氢-9-H-吡啶[3,4-b]吲哚
97%
别名:
6-甲氧基-1,2,3,4-四氢-β-咔啉
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关于此项目
经验公式（希尔记法）:
C12H14N2O
化学文摘社编号:
分子量:
202.25
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12171500
MDL number:
InChI
1S/C12H14N2O/c1-15-8-2-3-11-10(6-8)9-4-5-13-7-12(9)14-11/h2-3,6,13-14H,4-5,7H2,1H3
SMILES string
COc1ccc2[nH]c3CNCCc3c2c1
InChI key
QYMDEOQLJUUNOF-UHFFFAOYSA-N
assay
97%
form
powder or crystals
mp
219-222 °C (lit.)
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
Gene Information
rat ... Htr2a(29595), Htr2c(25187)
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
M Aranda et al.
Journal of pineal research, 49(1), 78-85 (2010-06-08)
The protective in vivo effects of melatonin or pinoline on carbon tetrachloride (CCl(4))-induced oxidative damage were investigated in liver of rats and compared to rats injected only with CCl(4) (5 mL/kg body weight). Hepatic cell membrane fluidity, monitored using fluorescence
J Mekhloufi et al.
Journal of pineal research, 39(1), 27-33 (2005-06-28)
This study aimed at investigating the in vitro protective effects of GWC22, a novel pinoline derivative [6-ethyl-1-(3-methoxyphenyl)-2-propyl-1,2,3,4-tetrahydro-beta-carboline] chlorhydrate, against radiation-induced oxidation of linoleate initiated by hydroxyl radicals ((*)OH). Using linoleate micelles (10(-2) m) as lipid model, two indexes of peroxidation
Sergio Millán-Plano et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 17(1), 39-44 (2003-05-21)
The serum concentrations of aluminum, a metal potentially involved in the pathogenesis of Alzheimer's disease, increase with age. Also, intense and prolonged exposure to aluminum may result in dementia. Melatonin and pinoline are two well known antioxidants that efficiently reduce
E Jane Cooper et al.
European journal of pharmacology, 482(1-3), 189-196 (2003-12-09)
It is well known that certain imidazoline compounds can stimulate insulin secretion and this has been attributed to the activation of imidazoline I(3) binding sites in the pancreatic beta-cell. Recently, it has been proposed that beta-carbolines may be endogenous ligands
Xi-Ling Jiang et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(3), 443-446 (2008-12-20)
Pinoline, 6-methoxy-1,2,3,4-tetrahydro-beta-carboline, is a serotonin analog that selectively inhibits the activity of monoamine oxidase-A and shows antidepressant activity. Our previous study using a panel of recombinant cytochrome P450 (P450) enzymes suggests that pinoline O-demethylation may be selectively catalyzed by polymorphic
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