assay
99%
form
solid
bp
145-147 °C/10 mmHg (lit.)
mp
139-141 °C (lit.)
functional group
bromo, nitro
SMILES string
[O-][N+](=O)c1ccc(Br)nc1
InChI
1S/C5H3BrN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H
InChI key
HUUFTVUBFFESEN-UHFFFAOYSA-N
Application
2-Bromo-5-nitropyridine was used in preparation of boc-protected (piperazin-1-ylmethyl)biaryls via microwave-mediated Suzuki-Miyaura coupling with (boc-piperazin-1-ylmethyl)phenylboronic acid pinacol esters. It was also used in the synthesis of 2-pyridyl analogs.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Hashim Motiwala et al.
Bioorganic & medicinal chemistry letters, 21(19), 5812-5817 (2011-08-27)
The diacylglycerol acyltransferase enzyme, DGAT1, presents itself as a potential target for obesity as this enzyme is dedicated to the final committed step in triglyceride biosynthesis. Biphenyl ureas, exemplified by compound 4, have been reported to be potent hDGAT1 inhibitors.
Synthesis of a (piperazin-1-ylmethyl) biaryl library via microwave-mediated Suzuki-Miyaura cross-couplings.
Spencer J, et al.
Tetrahedron Letters, 52(31), 3963-3968 (2011)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 324833-5G | 04061826711828 |
| 324833-1G | 04061825753249 |