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359343

氢化奎尼定

Name: 氢化奎尼定
Brand: ALDRICH

95%

别名:

双氢奎尼丁

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₆N₂O₂

化学文摘社编号:

1435-55-8

分子量:

326.43

UNSPSC Code:

12352005

NACRES:

NA.22

PubChem Substance ID:

24862070

EC Number:

215-862-5

Beilstein/REAXYS Number:

91441

MDL number:

MFCD00135599

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属性

Quality Segment

100

assay

95%

optical activity

[α]25/D +226°, c = 2 in ethanol

mp

169-170 °C (lit.)

functional group

hydroxyl

SMILES string

CC[C@H]1CN2CCC1CC2[C@@H](O)c3ccnc4ccc(OC)cc34

InChI

1S/C20H26N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h4-6,8,11,13-14,19-20,23H,3,7,9-10,12H2,1-2H3/t13-,14-,19+,20-/m0/s1

InChI key

LJOQGZACKSYWCH-LHHVKLHASA-N

Gene Information

human ... CYP2D6(1565)

说明

General description

Hydroquinidine, a cinchona alkaloid, is a structural analog of quinidine. It shows antiarrhythmic effect.

Application

Hydroquinidine can be used as a chiral catalyst to prepare:

Enantioselective axially chiral phosphamides by N-allylic alkylation reaction between Morita-Baylis-Hillamn (MBH) carbonate and phosphamides.
Enantioselective α-amino phosphonates by hydrophosphonylation of N-aryl ketimines.
Enantioselective α-hydrazino esters by α-hydrazination of 3-oxoindolines using azodicarboxylate via aza-Michael reaction.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c