361046
碘芬酸
97%
别名:
α-乙基-3-羟基-2,4,6-三碘氢化肉桂酸
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关于此项目
线性分子式:
HOC6H(I)3CH2CH(C2H5)CO2H
化学文摘社编号:
分子量:
571.92
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
产品名称
碘芬酸, 97%
InChI
1S/C11H11I3O3/c1-2-5(11(16)17)3-6-7(12)4-8(13)10(15)9(6)14/h4-5,15H,2-3H2,1H3,(H,16,17)
SMILES string
CCC(Cc1c(I)cc(I)c(O)c1I)C(O)=O
InChI key
GOIQOQCNFWYSTQ-UHFFFAOYSA-N
assay
97%
form
solid
mp
146-148 °C (lit.)
functional group
carboxylic acid
iodo
Quality Level
Application
α-Ethyl-3-hydroxy-2,4,6-triiodohydrocinnamic acid (iophenoxic acid ) was used as marker in “bait acceptance” studies conducted on various animal species. It was used in the direct quantitation of iophenoxic acid in porcine serum samples by a liquid chromatographic-electrospray ionization mass spectrometric technique.
General description
α-Ethyl-3-hydroxy-2,4,6-triiodohydrocinnamic acid (Iophenoxic acid ) is an organic, iodine-containing compound. Iophenoxic acid is an iodinated radiocontrast agent, its clinical use has been withdrawn due to its exceptionally long half-life in the body, since it has high-affinity binding to human serum albumin (HSA). Structural basis of its interaction with HSA has been evaluated.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Carlo Bertucci et al.
Farmaco (Societa chimica italiana : 1989), 58(9), 901-908 (2003-09-19)
The binding of two cholecystographic agents to human serum albumin (HSA) was evaluated by means of two different complementary methodologies. In particular, the inhibition of drug HSA binding caused by iopanoic- and iophenoxic-acid was investigated by circular dichroism (CD) and
C T Eason et al.
Xenobiotica; the fate of foreign compounds in biological systems, 22(2), 185-189 (1992-02-01)
1. The comparative plasma pharmacokinetics of two organic iodine-containing compounds were evaluated in the goat for their suitability as markers in wildlife studies. 2. After oral administration of a single dose, the plasma elimination half-life for iopanoic acid was considerably
A Jones
Journal of chromatography. B, Biomedical applications, 654(2), 293-296 (1994-04-01)
Iophenoxic acid (IPA), a marker used to investigate the feeding behaviour of bait-consuming animals has previously been indirectly determined by measuring protein-bound iodine levels in serum or plasma. For the first time a method is reported for the direct determination
Ali J Ryan et al.
BMC structural biology, 11, 18-18 (2011-04-20)
Iophenoxic acid is an iodinated radiocontrast agent that was withdrawn from clinical use because of its exceptionally long half-life in the body, which was due in part to its high-affinity binding to human serum albumin (HSA). It was replaced by
U Kragh-Hansen
Molecular pharmacology, 34(2), 160-171 (1988-08-01)
The relations between the single high affinity binding sites for azapropazone, phenylbutazone, chlorpropamide, sulfathiazole, and iophenoxate and the binding regions of human serum albumin represented by the marker ligands diazepam, phenol red, salicylate, and warfarin were examined by a series
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