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文件

363057

6-O-甲基鸟嘌呤

Name: 6-<I>O</I>-甲基鸟嘌呤
Brand: ALDRICH

97%

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所有图片(1)

别名:

2-氨基-6-甲氧基嘌呤, 6-甲氧基鸟嘌呤

经验公式（希尔记法）:

C₆H₇N₅O

CAS号:

20535-83-5

分子量:

165.15

Beilstein:

645384

MDL编号:

MFCD00133009

PubChem化学物质编号:

24862349

NACRES:

NA.22

检测方案

97%

mp

>300 °C (lit.)

SMILES字符串

COc1nc(N)nc2[nH]cnc12

InChI

1S/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)

InChI key

BXJHWYVXLGLDMZ-UHFFFAOYSA-N

基因信息

human ... CDK2(1017) , MGMT(4255)

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一般描述

6-O-甲基鸟嘌呤是一种嘌呤衍生物，它的结合亲和力已通过使用等温滴定热法（ITC）利用枯草芽孢杆菌xpt-pbuX鸟嘌呤核糖开关（GR）进行了检查。6-O-甲基鸟嘌呤是在一系列纯化的tRNA制剂的烷基化过程中通过与致癌物N-甲基-N-亚硝基脲反应而形成的。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.

Vitaly F Latypov et al.

Molecular cell, 47(1), 50-60 (2012-06-05)

Nucleotide excision repair (NER) has long been known to remove DNA lesions induced by chemical carcinogens, and the molecular mechanism has been partially elucidated. Here we demonstrate that in Schizosaccharomyces pombe a DNA recognition protein, alkyltransferase-like 1 (Atl1), can play

Undetectable role of oxidative DNA damage in cell cycle, cytotoxic and clastogenic effects of Cr(VI) in human lung cells with restored ascorbate levels.

Mindy Reynolds et al.

Mutagenesis, 27(4), 437-443 (2012-01-14)

Cultured human cells are invaluable biological models for mechanistic studies of genotoxic chemicals and drugs. Continuing replacement of animals in toxicity testing will further increase the importance of in vitro cell systems, which should accurately reproduce key in vivo characteristics

Alkylation of transfer RNA by N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea.

A E Pegg

Chemico-biological interactions, 6(6), 393-406 (1973-06-01)

Simultaneous quantification of methylated purines in DNA by isotope dilution LC-MS/MS coupled with automated solid-phase extraction.

Chiung-Wen Hu et al.

Analytical and bioanalytical chemistry, 402(3), 1199-1208 (2011-11-19)

Since methylation at the N-7 and O(6) positions of guanine and the N-3 position of adenine in DNA are the predominant reaction sites, N(7)-methylguanine (N(7)-MeG), O(6)-methylguanine (O(6)-MeG), and N(3)-methyladenine (N(3)-MeA) have been suggested as good biomarkers for assessing exposure to

Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.

Sharon E Murphy et al.

Cancer prevention research (Philadelphia, Pa.), 4(11), 1752-1760 (2011-10-27)

Nicotine replacement therapy is often used to maintain smoking cessation. However, concerns exist about the safety of long-term nicotine replacement therapy use in ex-smokers and its concurrent use in smokers. In this study, we determined the effect of nicotine administration

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