363057
6-O-甲基鸟嘌呤
97%
别名:
2-氨基-6-甲氧基嘌呤, 6-甲氧基鸟嘌呤
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C6H7N5O
化学文摘社编号:
分子量:
165.15
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
645384
产品名称
6-O-甲基鸟嘌呤, 97%
InChI
1S/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)
SMILES string
COc1nc(N)nc2[nH]cnc12
InChI key
BXJHWYVXLGLDMZ-UHFFFAOYSA-N
assay
97%
mp
>300 °C (lit.)
Quality Level
Gene Information
human ... CDK2(1017), MGMT(4255)
正在寻找类似产品? 访问 产品对比指南
General description
6-O-甲基鸟嘌呤是一种嘌呤衍生物，它的结合亲和力已通过使用等温滴定热法（ITC）利用枯草芽孢杆菌xpt-pbuX鸟嘌呤核糖开关（GR）进行了检查。6-O-甲基鸟嘌呤是在一系列纯化的tRNA制剂的烷基化过程中通过与致癌物N-甲基-N-亚硝基脲反应而形成的。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Chiung-Wen Hu et al.
Analytical and bioanalytical chemistry, 402(3), 1199-1208 (2011-11-19)
Since methylation at the N-7 and O(6) positions of guanine and the N-3 position of adenine in DNA are the predominant reaction sites, N(7)-methylguanine (N(7)-MeG), O(6)-methylguanine (O(6)-MeG), and N(3)-methyladenine (N(3)-MeA) have been suggested as good biomarkers for assessing exposure to
Alkylation of transfer RNA by N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea.
A E Pegg
Chemico-biological interactions, 6(6), 393-406 (1973-06-01)
Delia Chavarria et al.
Journal of molecular biology, 412(3), 325-339 (2011-08-09)
O(6)-methylguanine (O(6)-MeG) is a miscoding DNA lesion arising from the alkylation of guanine. This report uses the bacteriophage T4 DNA polymerase as a model to probe the roles of hydrogen-bonding interactions, shape/size, and nucleobase desolvation during the replication of this
V V Lylo et al.
TSitologiia i genetika, 45(6), 53-60 (2012-02-15)
The aim of our study was to investigate the effect of recombinant human cytokine EMAP II (endothelial monocyte-activating polypeptide II) on the expression of MGMT gene, encoding repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) in human cell cultures. The influence of EMAP
Jihong Zhang et al.
Current molecular pharmacology, 5(1), 102-114 (2011-11-30)
Glioblastoma multiforme is the most common aggressive adult primary tumour of the central nervous system. Treatment includes surgery, radiotherapy and adjuvant temozolomide (TMZ) chemotherapy. TMZ is an alkylating agent prodrug, delivering a methyl group to purine bases of DNA (O6-guanine;
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持