InChI key
AQLLDCFUQXGLHM-UHFFFAOYSA-N
InChI
1S/C8H8FNO/c1-6(11)10-8-4-2-3-7(9)5-8/h2-5H,1H3,(H,10,11)
SMILES string
CC(=O)Nc1cccc(F)c1
assay
98%
mp
82-84 °C (lit.)
solubility
methanol: soluble 25 mg/mL, clear, colorless to yellow
General description
3′-Fluoroacetanilide is a substituted acetanilide. Fieldel-Crafts acylation of 3-fluoroacetanilide with chloroacetyl chloride is reported to yield 2′-fluoro-4′-acteamido-2-(1H-1,2,4-triazole-1-yl) acetophenone. Nitration of 3-fluoroacetanilide with nitronium tetrafluoroborate is reported.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Nitrations of acetanilides by reagents of NO2X type.
Lynch BM, et al.
Canadian Journal of Chemistry, 46(7), 1141-1152 (1968)
E Livni et al.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 19(2), 191-199 (1992-02-01)
[4-18F] 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-l-yl)-2-propanol [( 4-18F] fluconazole) was synthesized from its amino precursor. Fieldel-Crafts acylation of 3-fluoroacetanilide with chloroacetyl chloride produced 2'-fluoro-4'-acteamido-2-(1H-1,2,4-triazole-1-yl) acetophenone in 12% yield. Sequential reaction with (1) dimethylsulphoxonium methylide and (2) 1,2,4-triazole followed by in situ hydrolysis resulted in
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