主要文件

查看所有文档

363960

(S,R)-诺司卡品

Name: (<I>S,R</I>)-诺司卡品
Brand: ALDRICH

97%

别名:

α-Narcotine, (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₂H₂₃NO₇

化学文摘社编号:

128-62-1

分子量:

413.42

NACRES:

NA.22

PubChem Substance ID:

24862408

UNSPSC Code:

12352005

EC Number:

204-899-2

MDL number:

MFCD00069316

Assay:

97%

Form:

solid

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

assay

97%

form

solid

optical activity

[α]20/D −200°, c = 1 in chloroform

mp

174-176 °C (lit.)

functional group

ester

SMILES string

COc1ccc2C(OC(=O)c2c1OC)C3N(C)CCc4cc5OCOc5c(OC)c34

InChI

1S/C22H23NO7/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18/h5-6,9,17-18H,7-8,10H2,1-4H3/t17-,18+/m1/s1

InChI key

AKNNEGZIBPJZJG-MSOLQXFVSA-N

说明

General description

(S,R)-Noscapine is a phthalideisoquinoline alkaloid found in opium. It is an antimicrotubule agent that also shows potent antitumor activity.

Application

Noscapine may be used as a source to synthesize its bromo-derivatives, which has higher tubulin binding activity when compared to noscapine. Its 3,4,5-trimethoxybenzyl analog is a potential antitumor agent.

pictograms

GHS07

signalword

Warning

hcodes

H302,H336

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

target_organs

Central nervous system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin).

Pradeep K Naik et al.

Journal of computer-aided molecular design, 26(2), 233-247 (2011-12-16)

Our screen for tubulin-binding small molecules that do not depolymerize bulk cellular microtubules, but based upon structural features of well known microtubule-depolymerizing colchicine and podophyllotoxin, revealed tubulin binding anti-cancer property of noscapine (Ye et al. in Proc Natl Acad Sci

Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation.

Zhou J, et al.

Molecular Pharmacology, 63(4), 799-807 (2003)

A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine.

Thilo Winzer et al.

Science (New York, N.Y.), 336(6089), 1704-1708 (2012-06-02)

Noscapine is an antitumor alkaloid from opium poppy that binds tubulin, arrests metaphase, and induces apoptosis in dividing human cells. Elucidation of the biosynthetic pathway will enable improvement in the commercial production of noscapine and related bioactive molecules. Transcriptomic analysis

查看所有相关文献

全球贸易项目编号

货号	GTIN
363960-5G	04061831825213