365602
青藤碱
0.3 mol chloroform of crystallization
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关于此项目
经验公式（希尔记法）:
C19H23NO4 · 0.3CHCl3
化学文摘社编号:
分子量:
365.20
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
InChI
1S/C19H23NO4/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19/h4-5,9,12-13,22H,6-8,10H2,1-3H3/t12-,13+,19-/m1/s1
SMILES string
COC1=CC2[C@@H]3Cc4ccc(OC)c(O)c4[C@]2(CCN3C)CC1=O
InChI key
INYYVPJSBIVGPH-QHRIQVFBSA-N
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
impurities
0.3 mol chloroform of crystallization
mp
180 °C (dec.) (lit.)
functional group
ether, ketone
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Liver,Kidney, Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Lihua Zhu et al.
Molecular and cellular biochemistry, 373(1-2), 53-62 (2012-10-16)
Sinomenine, a pure alkaloid extract from Sinomenium acutum, has anti-inflammatory and immunoregulatory functions. This study investigated the efficiency and the signalling pathways involved in the effect of sinomenine on vascular smooth muscle cell (VSMC) dedifferentiation in response to platelet-derived growth
Xiao-Ling Wang et al.
Journal of Asian natural products research, 13(6), 523-528 (2011-05-31)
Two new morphinane alkaloids, 1-hydroxy-10-oxo-sinomenine (1) and 4,5-epoxy-14-hydroxy sinomenine N-oxide (2), have been isolated from the stems of Sinomenium acutum. Their structures were established by various spectral analyses, especially 2D NMR experiments. The structure of 2 was confirmed by single
Lie Xiong et al.
Immunotherapy, 4(8), 785-791 (2012-09-06)
To evaluate the immunosuppressive efficacy of alkaloid sinomenine (SIN) and the synergistic effects in combination with cyclosporin A (CsA) in acute rejection after rat renal allograft. Animals were treated with saline in group 1, SIN (30 mg/kg/d) in group 2
David Pérol et al.
BMC cancer, 12, 603-603 (2012-12-19)
Chemotherapy induced nausea and vomiting (CINV) remains a major problem that seriously impairs the quality of life (QoL) in cancer patients receiving chemotherapy regimens. Complementary medicines, including homeopathy, are used by many patients with cancer, usually alongside with conventional treatment.
Xiang-Xiang Zhao et al.
Pharmaceutical biology, 50(8), 1053-1061 (2012-07-11)
Sinomenium acutum (Thumb.) Rehd. et Wils. (Menispermaceae, SA) has been used as a traditional Chinese medicine in the treatment of various diseases for hundreds of years; it possesses favorable effects against autoimmune diseases, especially rheumatoid arthritis (RA). A great number
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