367737
三甲基（三氟甲基）硅烷 溶液
0.5 M in THF
别名:
(Trifluoromethyl)trimethylsilane, TFMTMS
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关于此项目
线性分子式:
(CH3)3SiCF3
化学文摘社编号:
分子量:
142.19
PubChem Substance ID:
UNSPSC Code:
12352101
Beilstein/REAXYS Number:
4241868
MDL number:
SMILES string
C[Si](C)(C)C(F)(F)F
InChI
1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3
InChI key
MWKJTNBSKNUMFN-UHFFFAOYSA-N
vapor pressure
10.98 psi ( 55 °C), 2.8 psi ( 20 °C)
form
liquid
concentration
0.5 M in THF
bp
40 °C
density
0.895 g/mL at 25 °C
Application
参与三氟甲基的亲核加成反应生成醛和酮。
Reactant for:
- Silver-mediated C-H trifluoromethylation of arenes
- Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8
- Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts
- Palladium-catalyzed oxidative trifluoromethylation of indoles
- Preparation of 5-HT1A antagonists
- Used as difluorocarbene source
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
target_organs
Respiratory system
supp_hazards
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
1.4 °F - closed cup
flash_point_c
-17 °C - closed cup
法规信息
危险化学品
此项目有
Journal of the American Chemical Society, 111, 393-393 (1989)
The Journal of Organic Chemistry, 57, 1124-1124 (1992)
J W Skiles et al.
Journal of medicinal chemistry, 35(4), 641-662 (1992-02-21)
A series of tripeptides possessing trifluoromethyl or aryl ketone residues at P1 were prepared and evaluated both in vitro and in vivo as potential inhibitors of human leukocyte elastase (HLE). Tripeptides containing non naturally occurring N-substituted glycine residues at the
G K Surya Prakash et al.
The Journal of organic chemistry, 71(18), 6806-6813 (2006-08-26)
Organofluorine compounds are becoming increasingly important in different fields, such as material science, agro chemistry, and the pharmaceutical industry. Nucleophilic trifluoromethylation is one of the widely used methods to incorporate a trifluoromethyl moiety into organic molecules. We have carried out
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