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Merck
CN

371858

6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole hydrochloride

97%

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经验公式(希尔记法):
C12H14N2O · HCl
化学文摘社编号:
分子量:
238.71
UNSPSC Code:
12171500
PubChem Substance ID:
MDL number:
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InChI

1S/C12H14N2O.ClH/c1-15-8-2-3-11-10(6-8)9-4-5-13-7-12(9)14-11;/h2-3,6,13-14H,4-5,7H2,1H3;1H

SMILES string

Cl[H].COc1ccc2[nH]c3CNCCc3c2c1

InChI key

KRMJEIDSHZEQHJ-UHFFFAOYSA-N

assay

97%

mp

288-290 °C (lit.)

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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G Piñol-Ripoll et al.
Neuroscience letters, 405(1-2), 89-93 (2006-07-21)
Nitric oxide (NO) is a physiological neurotransmitter, a mediator of the excitatory neurotransmitter glutamate pathways that regulates several neuroendocrine functions, but excessive NO is toxic by itself and it interacts with superoxide radical (O(2)(-)) to form the peroxynitrite anion (ONOO(-)).
W A Müller et al.
The International journal of developmental biology, 42(6), 825-828 (1998-09-04)
Support or inhibition of DAG-induced head formation: Hydra magnipapillata can be caused to form ectopic head structures by periodictreatmentwith PKC activators such as diacylglycerol (DAG). This ectopic head formation is supported by an extract from the ovine pineal gland that
Anne-Catherine Durand et al.
Journal of enzyme inhibition and medicinal chemistry, 22(5), 556-562 (2007-11-27)
In order to predict the antioxidant activity of 22 pinoline derivatives (1,2,3,4-tetrahydro-beta-carbolines), two dimensional quantitative-structure activity relationships (2D-QSAR) analysis of 19 hexahydropiridoindoles and 12 flavonoids was realized. Five statistically significant models were obtained from randomly constituted training sets (21 compounds)
Xi-Ling Jiang et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(3), 443-446 (2008-12-20)
Pinoline, 6-methoxy-1,2,3,4-tetrahydro-beta-carboline, is a serotonin analog that selectively inhibits the activity of monoamine oxidase-A and shows antidepressant activity. Our previous study using a panel of recombinant cytochrome P450 (P450) enzymes suggests that pinoline O-demethylation may be selectively catalyzed by polymorphic
Gordon Y Tang et al.
Neuroscience letters, 412(3), 191-194 (2006-11-28)
Glutamate is a neurotransmitter associated with oxidative retinal disorders. Pinoline (PIN) and N-acetylserotonin (NAS) are newly identified neural protectors. We investigated the glutamate-induced lipid peroxidation (LPO) and the protective effects of PIN and NAS in the retina. Porcine retinal homogenates

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