380253
2-哌啶甲酸乙酯 盐酸盐
97%
别名:
2-哌啶羧酸乙酯 盐酸盐
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关于此项目
经验公式（希尔记法）:
C8H15NO2 · HCl
化学文摘社编号:
分子量:
193.67
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
方案
97%
mp
211-213 °C (lit.)
SMILES字符串
Cl[H].CCOC(=O)C1CCCCN1
InChI
1S/C8H15NO2.ClH/c1-2-11-8(10)7-5-3-4-6-9-7;/h7,9H,2-6H2,1H3;1H
InChI key
KGAWPIXNSIYQPC-UHFFFAOYSA-N
一般描述
Ethyl pipecolinate hydrochloride is a heterocyclic building block. It is reported to participate in the total synthesis of the (+)-epiquinamide, a quinolizidine alkaloid.
应用
Ethyl pipecolinate hydrochloride (Ethyl 2-piperidinecarboxylate hydrochloride) may be used in the preparation of:
- 1,4-diazabicyclo[4.4.0]decane
- small molecule inhibitors of Legionella MIP protein
- antiinflammatory and analgesic molecules
- anti-amnesic agents
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Christina Juli et al.
Journal of medicinal chemistry, 54(1), 277-283 (2010-12-15)
The macrophage infectivity potentiator (MIP) protein is a major virulence factor of Legionella pneumophila, the causative agent of Legionnaires' disease. MIP belongs to the FK506-binding proteins (FKBP) and is necessary for optimal intracellular survival and lung tissue dissemination of L.
A concise synthesis of (?) and a total synthesis of (+)-epiquinamide.
Tong STA and Barker D.
Tetrahedron Letters, 47(29), 5017-5020 (2006)
Syntheses of 1, 4-Diazabicyclo [4.4. 0] decanes, 1, 4-Diazabicyclo [4.3. 0] nonanes and 1, 8-Diazabicyclo [4.3. 0] nonanes.
Freed ME and Day AR.
J. Org. React., 25(12), 2108-2113 (1960)
S Zhao et al.
Bioorganic & medicinal chemistry, 7(8), 1637-1646 (1999-09-11)
Tacrine, one of the drugs available for Alzheimer's disease based on the cholinergic approach, suffers from considerable toxicity. Many analogues of tacrine have been prepared which retain the pharmacologically rich aminopyridine or aminoquinoline motifs. The current research was undertaken to
G. A. Gevorgyan, et al.,
Khim.-Farm. Zh., 37, 152-154 (2003)
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