390585
次异羟肟酸
95%
别名:
软木肟酸, SBHA, 辛二酰基双异羟肟酸
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关于此项目
线性分子式:
[-(CH2)3CONHOH]2
化学文摘社编号:
分子量:
204.22
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
95%
Quality Level
assay
95%
mp
153-155 °C (lit.)
functional group
amine
SMILES string
ONC(=O)CCCCCCC(=O)NO
InChI
1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)
InChI key
IDQPVOFTURLJPT-UHFFFAOYSA-N
Biochem/physiol Actions
HDAC 抑制剂
软木肟酸(SBHA)是组蛋白脱乙酰基酶（HDAC）抑制剂。SBHA 抑制 HDAC1 和 HDAC3 的活性，IC50 值分别为 250 和 300 nM。SBHA 抑制增殖，并诱导几种癌细胞系的凋亡。研究表明，SBHA 可激活甲状腺髓样癌（MTC）细胞中的 Notch 信号传导。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Li Ning et al.
The oncologist, 13(2), 98-104 (2008-02-29)
Medullary thyroid carcinoma (MTC) is a neuroendocrine (NE) malignancy that frequently metastasizes and has limited treatments. We recently reported that ectopic expression of Notch-1 in human MTC cells suppresses growth. The objective of this study was to evaluate the ability
Jiansen Li et al.
Oncology reports, 37(1), 458-464 (2016-12-23)
Anaplastic thyroid cancer (ATC), usually derived from well-differentiated thyroid cancers is one of the most lethal human endocrine malignancies. In the present study, we report that in human ATC tumor tissue samples exist undetectable Notch1 and the active Notch1 intracellular
Denisa Hrckova Drozdkova et al.
Anticancer research, 40(9), 4979-4987 (2020-09-04)
Multiple myeloma is a highly heterogeneous disease of clonal plasma cells. Histone deacetylase (HDAC) inhibitors are promising anticancer drugs but their precise mechanisms of actions are not well understood. Cell-cycle regulation and pro-apoptotic effects of two histone deacetylase inhibitors, suberohydroxamic
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 390585-1G | 04061831972672 |