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Merck
CN

392499

3,4-二甲基-1-碘苯

99%

别名:

4-碘邻二甲苯

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线性分子式:
(CH3)2C6H3I
化学文摘社编号:
分子量:
232.06
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
99%
Form:
liquid
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产品名称

3,4-二甲基-1-碘苯, 99%

InChI

1S/C8H9I/c1-6-3-4-8(9)5-7(6)2/h3-5H,1-2H3

SMILES string

Cc1ccc(I)cc1C

InChI key

CSFRCLYFVINMBZ-UHFFFAOYSA-N

assay

99%

form

liquid

refractive index

n20/D 1.603 (lit.)

bp

106-108 °C/13 mmHg (lit.)

density

1.633 g/mL at 25 °C (lit.)

Application

1-Iodo-3,4-dimethylbenzene (4-iodo-o-xylene, 3,4-dimethyliodobenzene) may be used in the synthesis of the following:
  • 3-arylacrylamide
  • 3,3-diaryl substituted acrylamide
  • 3-arylpropylamine
  • di-tert-butyl 1-(3,4-dimethylphenyl)hydrazine-1,2-dicarboxylate
  • 2,3,7,8-tetramethyldibenzofuran
  • N-(3-(3,4-Dimethylphenyl)-2-phthalimidopropionyl)-2-methylthioaniline

General description

1-Iodo-3,4-dimethylbenzene (4-iodo-o-xylene, 3,4-dimethyliodobenzene) is an aryl halide. Its synthesis, NMR and IR spectra has been reported. Its nitration reaction and copper catalyzed trifluoromethylation reaction has been studied.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

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Dmitry Shabashov et al.
Journal of the American Chemical Society, 132(11), 3965-3972 (2010-02-24)
We have developed a method for auxiliary-directed, palladium-catalyzed beta-arylation and alkylation of sp(3) and sp(2) C-H bonds in carboxylic acid derivatives. The method employs a carboxylic acid 2-methylthioaniline- or 8-aminoquinoline amide substrate, aryl or alkyl iodide coupling partner, palladium acetate
ipso-Nitration of 4-iodo-o-xylene.
Zweig A, et al.
The Journal of Organic Chemistry, 42(25), 4049-4052 (1977)
Martyn Inman et al.
The Journal of organic chemistry, 77(3), 1217-1232 (2011-10-08)
In a new variation on the Fischer indole synthesis, readily available haloarenes are converted into a wide range of indoles in just two steps by halogen-magnesium exchange and quenching with di-tert-butyl azodicarboxylate, followed by reaction with aldehydes or ketones under
Towards a practical and efficient copper-catalyzed trifluoromethylation of aryl halides.
Schareina T, et al.
Topics in Catalysis, 55(7-10), 426-431 (2012)
Synthesis of 2, 3, 7, 8-tetramethyldibenzofuran.
Mazere IV, et al.
Chemistry of Heterocyclic Compounds, 8(12), 1446-1448 (1972)

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