415057
硬脂酸镁
technical grade
别名:
十八酸 镁盐
等级
technical grade
质量水平
表单
powder
组成
palmitate salt, 25%
stearate salt, 65%
mp
200 °C (lit.)
SMILES字符串
CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC
InChI
1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
InChI key
HQKMJHAJHXVSDF-UHFFFAOYSA-L
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一般描述
硬脂酸镁（Mg-St）是硬脂酸的镁盐。已制备其脱水、二水和三水合物形式。已有研究描述了硬脂酸镁和乳糖颗粒混合片剂的制备。研究了混合时间对压缩片剂硬度、崩解时间和挤出力的影响。硬脂酸镁广泛用作制药工业中的润滑剂。它还在延缓溶解过程中发挥作用。已提出通过激光诱导击穿光谱法检测片剂中的硬脂酸镁。
硬脂酸镁，即硬脂酸的盐，在制药片剂中被广泛用作非活性成分。
硬脂酸镁，即硬脂酸的盐，在制药片剂中被广泛用作非活性成分。
应用
硬脂酸镁可用作双氯芬酸钠片剂处方中的辅料。可用于制备盐酸曲马多骨架片。
储存分类代码
11 - Combustible Solids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Effect of mixing time on the lubricating properties of magnesium stearate and the final characteristics of the compressed tablets.
Kikuta J-I and Kitamori N.
Drug Development and Industrial Pharmacy, 20(3), 343-355 (1994)
Delay effect of magnesium stearate on tablet dissolution in acidic medium.
Ariyasu A, et al.
International Journal of Pharmaceutics, 511(2), 757-764 (2016)
Physical characterization of the polymorphic variations of magnesium stearate and magnesium palmitate hydrate species.
Sharpe SA, et al.
Structural Chemistry, 8(1), 73-84 (1997)
Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential
Hobbs CA, et al.
Toxicology Reports, 4, 554-559 (2017)
Paola Bertocchi et al.
Journal of pharmaceutical and biomedical analysis, 37(4), 679-685 (2005-03-31)
The aim of this work was to compare the dissolution behaviour of six diclofenac sodium prolonged release tablets of different brands obtained from the national market. The formulations contain the same amount of drug substance but different types and/or amount
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