415294
5-碘-1,3-二甲基尿嘧啶
99%
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关于此项目
经验公式（希尔记法）:
C6H7IN2O2
化学文摘社编号:
分子量:
266.04
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
方案
99%
表单
solid
mp
225 °C (dec.) (lit.)
溶解性
DMSO: soluble 10 mg/mL(lit.)
SMILES字符串
CN1C=C(I)C(=O)N(C)C1=O
InChI
1S/C6H7IN2O2/c1-8-3-4(7)5(10)9(2)6(8)11/h3H,1-2H3
InChI key
XUUVRIXNFFFPCM-UHFFFAOYSA-N
一般描述
The effect of 5-iodo-1,3-dimethyluracil on the incorporation of [125I] 5-iodo-2′-deoxyuridine [125I radiolabelled IdUrd] in DNA of cancer cells has been studied. Synthesis of 5-iodo-1,3-dimethyluracil from aromatic organomercurials; 5-(acetoxymercurio)-1,3-dimethyluracil or 5,5′-mercuriobis(1,3-dimethyluracil) has been reported.
应用
5-Iodo-1,3-dimethyluracil may be used for the synthesis of N-[2-[(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)thio]-4-oxo[1]benzothieno[3,2-d]pyrimidin-3(4H)yl]methanesulfonamide.
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Yves M Dupertuis et al.
European journal of nuclear medicine and molecular imaging, 29(4), 499-505 (2002-03-27)
5-Iodo-2'-deoxyuridine (IdUrd), a thymidine (TdR) analogue, can be radiolabelled with iodine-125, an Auger radiation emitter, to provoke double-strand breaks once incorporated into DNA of cancer cells. We have previously shown that co-incubation of [125I]IdUrd with unlabelled IdUrd provided an additive
Organic iodine (I, III, and V) chemistry: 10 years of development at the Medical University of Warsaw, Poland.
Skulski L.
Molecules (Basel), 5(12), 1331-1371 (2000)
Mariarita Barone et al.
Molecular diversity, 17(3), 445-458 (2013-04-27)
The aim of this work was to evaluate the potential anti-inflammatory activity of eleven (5-15) new synthesized derivatives of benzo-thieno[3,2-d]pyrimidine on two cell models, namely human keratinocytes NCTC 2544 and mouse monocyte-macrophages J774. For the synthesis of test compounds an
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