415480
氯喹 二磷酸盐
97%
别名:
N4-(7-氯-4-喹啉基)-N1,N1-二甲基-1,4-戊二胺 二磷酸盐
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经验公式（希尔记法）:
C18H26ClN3 · 2H3PO4
化学文摘社编号:
分子量:
515.86
EC Number:
200-055-2
UNSPSC Code:
12352100
MDL number:
Beilstein/REAXYS Number:
4223142
InChI
1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
InChI key
QKICWELGRMTQCR-UHFFFAOYSA-N
SMILES string
OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
assay
97%
法规信息
新产品
此项目有
Kennett Sprogøe et al.
Journal of natural products, 71(4), 516-519 (2008-02-23)
Despite recent demonstration of the power of HPLC-PDA-MS-SPE-NMR (high-performance liquid chromatography-photodiode-array detection-mass spectrometry-solid-phase extraction-nuclear magnetic resonance) in structure determination of natural products directly from minute amounts of crude extracts, this technique leaves chirality of the compounds uncharacterized. In this work
Deepa Bahl et al.
Bioorganic & medicinal chemistry, 18(18), 6857-6864 (2010-08-20)
A useful concept for the rational design of antiparasitic drug candidates is the complexation of bioactive ligands with transition metals. In view of this, an investigation was conducted into a new set of metal complexes as potential antiplasmodium and antiamoebic
Onyeka Onyeibor et al.
Journal of medicinal chemistry, 48(7), 2701-2709 (2005-04-02)
A series of analogues of cryptolepine (1) have been synthesized and evaluated for their in vitro antiplasmodial and cytotoxic properties. The IC(50) values of several compounds (11a, 11k-m, 11o, 13) against Plasmodium falciparum (strain K1) were <0.1 muM, 5-10-fold lower
Changkun Hu et al.
European journal of medicinal chemistry, 45(2), 705-709 (2009-12-01)
The purpose of this study was to evaluate the enhancement value of chloroquine analogs when used in combination with Akt inhibitors on the MDA-MB468, MDA-MB231 and MCF7 human breast cancer cell lines. The result showed that the combination of certain
Margaret A L Blackie et al.
Bioorganic & medicinal chemistry letters, 20(3), 1078-1080 (2009-12-26)
Synthesis of the potent antiplasmodial 4-aminoquinoline, phenylequine (PQ), is reported for the first time. PQ and the two analogues show increased efficacy in moving from the chloroquine sensitive D10 to the chloroquine resistant K1 strain in vitro. The in vivo
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