441600
卡托普利
97%
别名:
N-[(S)-3-巯基-2-甲基丙酰基]-L-脯氨酸
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经验公式（希尔记法）:
C9H15NO3S
化学文摘社编号:
分子量:
217.29
Beilstein:
477887
EC 号:
MDL编号:
UNSPSC代码:
12352103
生化/生理作用
血管紧张素转换酶抑制剂。抑制血管紧张素 II 的形成，血管紧张素 II 是生物活性多肽，可促进血管生成并增加微血管密度。
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Ioanna Ntai et al.
Bioorganic & medicinal chemistry letters, 18(10), 3068-3071 (2007-12-22)
The naturally occurring phosphonotripeptide K-26 is a potent angiotensin converting enzyme (ACE) inhibitor containing an alpha-amino phosphonic acid analogue of tyrosine. Previous studies have demonstrated that canonical peptide analogues of K-26 are micromolar inhibitors of ACE. To ascertain the structure-activity
Jie Liu et al.
Bioorganic & medicinal chemistry letters, 19(6), 1822-1824 (2009-02-24)
This letter describes the total synthesis, preliminary biological evaluation and mechanism studies of a novel and structurally unique isochromanone, (+/-)7,8-dihydroxy-3-methyl-isochromanone-4 (1), a nature product contained in banana (Musa sapientum L.) peel. The bioassay showed that compound 1 displays potent antihypertensive
Maria C Breschi et al.
Journal of medicinal chemistry, 49(8), 2628-2639 (2006-04-14)
In a preliminary work, we reported two NO-sartans, possessing the characteristics of an AT(1) antagonist and a "slow NO donor", obtained by adding NO-donor side chains to losartan 1. The NO release from an NO-sartan should be modulated in order
Mohamed A H Ismail et al.
Bioorganic & medicinal chemistry, 17(10), 3739-3746 (2009-05-01)
A series of new 3-mercapto-2-methyl-propanoyl-pyrrolidine derivatives (V, VIa-e) were designed. A new validated ACE inhibitors pharmacophore model (hypothesis) was generated for the first time in this research from the biologically active (frozen) conformation of Lisinopril-Human ACE complex that was downloaded
Hiroshi Enomoto et al.
Bioorganic & medicinal chemistry letters, 18(16), 4529-4532 (2008-08-05)
We studied the synthetic modification of structurally similar N-mercaptoacyl-L-proline and (4R)-N-mercaptoacylthiazolidine-4-carboxylic acid to obtain potent leukotriene A(4) (LTA(4)) hydrolase inhibitors. An N-mercaptoacyl group, (2S)-3-mercapto-2-methylpropionyl group, was effective for both scaffolds. Additional introduction of a large substituent such as 4-isopropylbenzylthio (3f)
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