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Merck
CN

441600

卡托普利

97%

别名:

N-[(S)-3-巯基-2-甲基丙酰基]-L-脯氨酸

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经验公式(希尔记法):
C9H15NO3S
化学文摘社编号:
分子量:
217.29
EC Number:
263-607-1
UNSPSC Code:
12352103
MDL number:
Beilstein/REAXYS Number:
477887
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InChI

1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

InChI key

FAKRSMQSSFJEIM-RQJHMYQMSA-N

SMILES string

C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O

assay

97%

optical activity

[α]20/D −129°, c = 1.7 in ethanol

mp

104-108 °C (lit.)

Gene Information

human ... ACE(1636)

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Biochem/physiol Actions

血管紧张素转换酶抑制剂。抑制血管紧张素 II 的形成,血管紧张素 II 是生物活性多肽,可促进血管生成并增加微血管密度。

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Andreas G Tzakos et al.
Bioorganic & medicinal chemistry letters, 16(19), 5084-5087 (2006-08-08)
Enzyme-inhibitor recognition is considered one of the most fundamental aspects in the area of drug discovery. However, the molecular mechanism of this recognition process (induced fit or prebinding and adaptive selection among multiple conformers) in several cases remains unexplored. In
A Ma Velázquez et al.
European journal of medicinal chemistry, 43(3), 486-500 (2007-06-22)
We present in this work the synthesis and cardiovascular effects of new methylthiomorpholine compounds and they were compared with cardiovascular drugs such as captopril, losartan and omapatrilat.
Ioanna Ntai et al.
Bioorganic & medicinal chemistry letters, 18(10), 3068-3071 (2007-12-22)
The naturally occurring phosphonotripeptide K-26 is a potent angiotensin converting enzyme (ACE) inhibitor containing an alpha-amino phosphonic acid analogue of tyrosine. Previous studies have demonstrated that canonical peptide analogues of K-26 are micromolar inhibitors of ACE. To ascertain the structure-activity
Jie Liu et al.
Bioorganic & medicinal chemistry letters, 19(6), 1822-1824 (2009-02-24)
This letter describes the total synthesis, preliminary biological evaluation and mechanism studies of a novel and structurally unique isochromanone, (+/-)7,8-dihydroxy-3-methyl-isochromanone-4 (1), a nature product contained in banana (Musa sapientum L.) peel. The bioassay showed that compound 1 displays potent antihypertensive
Guo-Xiang Li et al.
European journal of medicinal chemistry, 44(12), 4841-4847 (2009-08-21)
Antioxidant capacities of captopril (CAP), 6-mercaptopurine (6-MP) and 9-(beta-D-ribofuranosyl)-6-mercaptopurine (6-MPR) were investigated by interacting them with 2,2'-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical, and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) cation radical (ABTS(+)(*)), and by protecting DNA and erythrocyte against 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH) induced oxidation. It was found

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