44162
1,3-双[双(2-吡啶基甲基)氨基]-2-丙醇 溶液
≥97.0% (HPLC), 10% in isopropanol
别名:
2-羟基-N,N,N′,N′-四(2-吡啶基甲基)-1,3-丙二胺
方案
≥97.0% (HPLC)
浓度
10% in isopropanol
密度
0.817 g/mL at 20 °C (lit.)
SMILES字符串
OC(CN(Cc1ccccn1)Cc2ccccn2)CN(Cc3ccccn3)Cc4ccccn4
其他说明
形成用于使 RNA 有效水解的双核金属配合物的配体；锌配合物的结构
法规信息
新产品
此项目有
H. Adams et al.
J. Chem. Soc., Dalton Trans., 925-925 (2002)
M Yashiro et al.
Journal of biochemistry, 120(6), 1067-1069 (1996-12-01)
A dinuclear La3+ complex hydrolyzes the phosphodiester bond in diribonucleotides efficiently under mild conditions. The rate of hydrolysis is remarkably accelerated on the complex formation between La3+ and TPHP (TPHP = N,N,N',N'-tetrakis [(2-pyridyl)methyl]-2-hydroxy-1,3-diaminopropane), and the highest activity is attained when
A Ishikubo et al.
Nucleic acids symposium series, 34(34), 85-86 (1995-01-01)
Dinuclear Zn(II) and La(III) complexes with TPHP efficiently hydrolyze a dinucleotide, ApA, under mild conditions (TPHP = N, N, N', N'-tetrakis[(2-pyridyl)-methyl]-2-hydroxy-1,3-diaminopropane). [Zn2(TPHP)]3+ hydrolyzes ApA with an extremely high activity; The pseudo-first-order rate constant is 8.4 x 10(-4) h-1 at pH
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