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Merck
CN

462047

Sigma-Aldrich

1-(2,6-二甲基苯氧基)-2-丙胺 盐酸盐

97%

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关于此项目

线性分子式:
(CH3)2C6H3OCH2CH(CH3)NH2·HCl
化学文摘社编号:
分子量:
215.72
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
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方案

97%

表单

solid

mp

200-203 °C (lit.)

SMILES字符串

Cl.CC(N)COc1c(C)cccc1C

InChI

1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H

InChI key

NFEIBWMZVIVJLQ-UHFFFAOYSA-N

一般描述

1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (Mexiletine) is an anti-arrhythmic agent having local anaesthetic activity. Mexiletine belongs to the triclinc crystal system, with the asymmetric unit containing two independent molecules.

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Sivy J, et al.
Acta Crystallographica Section C, Structural Chemistry, 47(12), 2695-2695 (1991)
Alessia Catalano et al.
Journal of medicinal chemistry, 55(3), 1418-1422 (2011-12-24)
The first synthesis of m-hydroxymexiletine (MHM) has been accomplished. MHM displayed hNav1.5 sodium channel blocking activity, and tests indicate it to be ∼2-fold more potent than the parent mexiletine and to have more favorable toxicological properties than mexiletine. Thus, MHM
Alessia Catalano et al.
Drug metabolism letters, 6(2), 124-128 (2012-08-02)
m-Hydroxymexiletine (MHM), a minor metabolite of the class IB anti-arrhythmic drug mexiletine, is about two fold more potent than the parent compound on human cardiac voltage-gated sodium channels (hNav1.5), and equipotent to mexiletine on human skeletal-muscle voltage-gated sodium channels (hNav1.4).
Drug-induced hypersensitivity syndrome complicated with concurrent fulminant type 1 diabetes mellitus and Hashimoto's thyroiditis.
Yusuke Minegaki et al.
International journal of dermatology, 52(3), 355-357 (2013-02-19)
Andrias O O'Reilly et al.
PloS one, 7(7), e41667-e41667 (2012-08-01)
Bisphenol A (BPA) has attracted considerable public attention as it leaches from plastic used in food containers, is detectable in human fluids and recent epidemiologic studies link BPA exposure with diseases including cardiovascular disorders. As heart-toxicity may derive from modified

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