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Merck
CN

462047

1-(2,6-二甲基苯氧基)-2-丙胺 盐酸盐

97%

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线性分子式:
(CH3)2C6H3OCH2CH(CH3)NH2·HCl
化学文摘社编号:
5370-01-4
分子量:
215.72
NACRES:
NA.22
PubChem Substance ID:
24869930
UNSPSC Code:
12352100
EC Number:
250-825-7
MDL number:
MFCD00216024
Assay:
97%
Form:
solid

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InChI key

NFEIBWMZVIVJLQ-UHFFFAOYSA-N

InChI

1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H

SMILES string

Cl.CC(N)COc1c(C)cccc1C

assay

97%

form

solid

mp

200-203 °C (lit.)

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

General description

1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (Mexiletine) is an anti-arrhythmic agent having local anaesthetic activity. Mexiletine belongs to the triclinc crystal system, with the asymmetric unit containing two independent molecules.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
09708AR

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Sivy J, et al.
Acta Crystallographica Section C, Structural Chemistry, 47(12), 2695-2695 (1991)
Jeffrey M Statland et al.
JAMA, 308(13), 1357-1365 (2012-10-04)
Nondystrophic myotonias (NDMs) are rare diseases caused by mutations in skeletal muscle ion channels. Patients experience delayed muscle relaxation causing functionally limiting stiffness and pain. Mexiletine-induced sodium channel blockade reduced myotonia in small studies; however, as is common in rare
A Jakob et al.
Klinische Padiatrie, 224(5), 309-312 (2011-12-16)
Erythromelalgia is a rare disorder characterized by recurrent pain attacks, swelling and redness in the distal extremities. The primary forms of the disorder are caused by mutations in voltage-gated sodium channels. Treatment is difficult and controlled therapeutic studies offer little
Michela De Bellis et al.
Biophysical journal, 104(2), 344-354 (2013-02-28)
Previously identified potent and/or use-dependent mexiletine (Mex) analogs were used as template for the rational design of new Na(v)-channel blockers. The effects of the novel analogs were tested on sodium currents of native myofibers. Data and molecular modeling show that
Erythromelagia: a rare and hard-to-treat condition: a 9-year-old boy responsive to intravenous lidocaine and oral mexilitene.
Francisca Elgueta et al.
Pain medicine (Malden, Mass.), 14(2), 311-312 (2013-02-02)
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