方案
97%
表单
solid
mp
200-203 °C (lit.)
SMILES字符串
Cl.CC(N)COc1c(C)cccc1C
InChI
1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
InChI key
NFEIBWMZVIVJLQ-UHFFFAOYSA-N
基因信息
一般描述
1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (Mexiletine) is an anti-arrhythmic agent having local anaesthetic activity. Mexiletine belongs to the triclinc crystal system, with the asymmetric unit containing two independent molecules.
Sivy J, et al.
Acta Crystallographica Section C, Structural Chemistry, 47(12), 2695-2695 (1991)
Alessia Catalano et al.
Journal of medicinal chemistry, 55(3), 1418-1422 (2011-12-24)
The first synthesis of m-hydroxymexiletine (MHM) has been accomplished. MHM displayed hNav1.5 sodium channel blocking activity, and tests indicate it to be ∼2-fold more potent than the parent mexiletine and to have more favorable toxicological properties than mexiletine. Thus, MHM
Alessia Catalano et al.
Drug metabolism letters, 6(2), 124-128 (2012-08-02)
m-Hydroxymexiletine (MHM), a minor metabolite of the class IB anti-arrhythmic drug mexiletine, is about two fold more potent than the parent compound on human cardiac voltage-gated sodium channels (hNav1.5), and equipotent to mexiletine on human skeletal-muscle voltage-gated sodium channels (hNav1.4).
Drug-induced hypersensitivity syndrome complicated with concurrent fulminant type 1 diabetes mellitus and Hashimoto's thyroiditis.
Yusuke Minegaki et al.
International journal of dermatology, 52(3), 355-357 (2013-02-19)
Andrias O O'Reilly et al.
PloS one, 7(7), e41667-e41667 (2012-08-01)
Bisphenol A (BPA) has attracted considerable public attention as it leaches from plastic used in food containers, is detectable in human fluids and recent epidemiologic studies link BPA exposure with diseases including cardiovascular disorders. As heart-toxicity may derive from modified
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