assay
98%
optical activity
[α]20/D −25°, c = 5 in 1 M NaOH
mp
270-276 °C (lit.)
SMILES string
CCCCC[C@H](N)P(O)(O)=O
Application
作为生物体系中氨基羧酸的具有吸引力的替代品。具有备受关注的多种有用属性，如用作肽类似物、 抗病毒试剂 半抗原，用于生成催化抗体、 酶抑制剂、 强效抗生素、 除草剂和农药。
法规信息
新产品
此项目有
Camp, N.P. et al.
Bioorganic & Medicinal Chemistry Letters, 2, 1047-1047 (1992)
M C Allen et al.
Journal of medicinal chemistry, 32(7), 1652-1661 (1989-07-01)
The synthesis of five amino phosphorus derivatives, 1a-e, is described. The derivatives were incorporated into a series (18) of analogues of the 5-14 portion of angiotensinogen, in most cases at the scissile Leu-Val bond. The resultant compounds were tested in
J Bird et al.
Journal of medicinal chemistry, 37(1), 158-169 (1994-01-07)
The synthesis of a series of N-phosphonalkyl dipeptides 6 is described. Syntheses were devised that allowed the preparation of single diastereoisomers and the assignment of stereochemistry. The compounds were evaluated in vitro for their ability to inhibit the degradation of