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Merck
CN

476951

Sigma-Aldrich

(2S,3S)-1,2-环氧-3-(Boc-氨基)-4-苯基丁烷

99%

别名:

[S-(R*,R*)]-(-)-(1-环氧乙基-2-苯乙基)氨基甲酸叔丁酯

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关于此项目

经验公式（希尔记法）:
C15H21NO3
化学文摘社编号:
98737-29-2
分子量:
263.33
MDL编号:
MFCD02258997
UNSPSC代码:
12352005
PubChem化学物质编号:
24871318
NACRES:
NA.22

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方案

99%

旋光性

[α]23/D −7°, c = 0.6 in methanol

mp

125-127 °C (lit.)

官能团

amine
ether
phenyl

SMILES字符串

[H][C@@]1(CO1)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C

InChI

1S/C15H21NO3/c1-15(2,3)19-14(17)16-12(13-10-18-13)9-11-7-5-4-6-8-11/h4-8,12-13H,9-10H2,1-3H3,(H,16,17)/t12-,13+/m0/s1

InChI key

NVPOUMXZERMIJK-QWHCGFSZSA-N

应用

(2S,3S)-1,2-Epoxy-3-(Boc-amino)-4-phenylbutane can be used as a reactant to prepare:
  • Hydroxyethyl urea peptidomimetics as potent γ-secretase inhibitors.
  • Arylsufonamide derivatives.
  • Peptidomimetic β-secretase inhibitors incorporating hydroxyethylamine isosteres.

象形图

Environment
GHS09

警示用语：

Warning

危险声明

H410

预防措施声明

P273 - P501

危险分类

Aquatic Acute 1 - Aquatic Chronic 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKBC3134
06323MH
14317DE
08214TD
94856MD

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Bioorganic & Medicinal Chemistry Letters, 14(4), 959-963 (2004)
Arun K Ghosh et al.
Journal of medicinal chemistry, 49(17), 5252-5261 (2006-08-18)
Structure-based design and synthesis of novel HIV protease inhibitors are described. The inhibitors are designed specifically to interact with the backbone of HIV protease active site to combat drug resistance. Inhibitor 3 has exhibited exceedingly potent enzyme inhibitory and antiviral
Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands
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Journal of medicinal chemistry, 49(25), 7342-7356 (2006)
Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance
Ghosh AK, et al.
Journal of medicinal chemistry, 49(17), 5252-5261 (2006)
Probing pockets S2-S4? of the ?-secretase active site with (hydroxyethyl) urea peptidomimetics
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Bioorganic & Medicinal Chemistry Letters, 14(8), 1935-1938 (2004)
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