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476951

(2S,3S)-1,2-环氧-3-(Boc-氨基)-4-苯基丁烷

Name: (2<I>S</I>,3<I>S</I>)-1,2-环氧-3-(Boc-氨基)-4-苯基丁烷
Brand: ALDRICH

99%

别名:

[S-(R*,R*)]-(-)-(1-环氧乙基-2-苯乙基)氨基甲酸叔丁酯

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关于此项目

经验公式（希尔记法）:

C₁₅H₂₁NO₃

化学文摘社编号:

98737-29-2

分子量:

263.33

NACRES:

NA.22

PubChem Substance ID:

24871318

UNSPSC Code:

12352005

MDL number:

MFCD02258997

Assay:

99%

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属性

assay

99%

optical activity

[α]23/D −7°, c = 0.6 in methanol

mp

125-127 °C (lit.)

functional group

amine, ether, phenyl

SMILES string

[H][C@@]1(CO1)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C

InChI

1S/C15H21NO3/c1-15(2,3)19-14(17)16-12(13-10-18-13)9-11-7-5-4-6-8-11/h4-8,12-13H,9-10H2,1-3H3,(H,16,17)/t12-,13+/m0/s1

InChI key

NVPOUMXZERMIJK-QWHCGFSZSA-N

说明

Application

(2S,3S)-1,2-Epoxy-3-(Boc-amino)-4-phenylbutane can be used as a reactant to prepare:

Hydroxyethyl urea peptidomimetics as potent γ-secretase inhibitors.
Arylsufonamide derivatives.
Peptidomimetic β-secretase inhibitors incorporating hydroxyethylamine isosteres.

pictograms

GHS09

signalword

Warning

hcodes

H410

pcodes

P273 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Novel arylsulfonamides possessing sub-picomolar HIV protease activities and potent anti-HIV activity against wild-type and drug-resistant viral strains.

John F Miller et al.

Bioorganic & medicinal chemistry letters, 14(4), 959-963 (2004-03-12)

A novel series of P1' chain-extended arylsufonamides was synthesized and evaluated for wild-type HIV protease inhibitory activity and in vitro antiviral activity against wild type virus and two protease inhibitor-resistant mutant viruses. All of the compounds showed dramatic increases in

Probing pockets S2-S4? of the ?-secretase active site with (hydroxyethyl) urea peptidomimetics

Esler WP, et al.

Bioorganic & Medicinal Chemistry Letters, 14(8), 1935-1938 (2004)

Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands.

Akbar Ali et al.

Journal of medicinal chemistry, 49(25), 7342-7356 (2006-12-08)

Here, we describe the design, synthesis, and biological evaluation of novel HIV-1 protease inhibitors incorporating N-phenyloxazolidinone-5-carboxamides into the (hydroxyethylamino)sulfonamide scaffold as P2 ligands. Series of inhibitors with variations at the P2 phenyloxazolidinone and the P2' phenylsulfonamide moieties were synthesized. Compounds

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货号	GTIN
476951-5G	04061832728483
476951-1G	04061825933801