488712
(三氟甲基)三甲基硅烷
99%
别名:
(Trifluoromethyl)trimethylsilane, Ruppert 试剂, TFMTMS
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关于此项目
线性分子式:
(CH3)3SiCF3
化学文摘社编号:
分子量:
142.19
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4241868
产品名称
(三氟甲基)三甲基硅烷, 99%
InChI
1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3
SMILES string
C[Si](C)(C)C(F)(F)F
InChI key
MWKJTNBSKNUMFN-UHFFFAOYSA-N
assay
99%
reaction suitability
reaction type: C-C Bond Formation
bp
54-55 °C (lit.)
density
0.962 g/mL at 20 °C (lit.)
functional group
fluoro
storage temp.
2-8°C
Quality Level
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Application
三甲基（三氟甲基）硅烷可以在以下过程中用作三氟甲基化剂：
- 将 N-(叔-丁基亚磺酰基）-亚胺转化为三氟甲基化胺
- 将反式-烯酮转化为反式-α-三氟甲基甲硅烷基醚
- 偶氮甲亚胺的三氟甲基化
- 将H-膦酸酯转化为CF3-膦酸酯
- 三氟甲基通过亲核加成转化成醛和酮。
signalword
Danger
hcodes
Hazard Classifications
Flam. Liq. 2 - Water-react 2
存储类别
4.3 - Hazardous materials which set free flammable gases upon contact with water
wgk
WGK 3
flash_point_f
1.4 °F - closed cup
flash_point_c
-17 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves
法规信息
危险化学品
此项目有
CsF-catalyzed nucleophilic trifluoromethylation of trans-enones with trimethyl (trifluoromethyl) silane: A facile synthesis of trans-?-trifluoromethyl allylic alcohols.
Singh R P, et al.
Organic Letters, 1(7), 1047-1049 (1999)
Copper-catalyzed aerobic oxidative trifluoromethylation of H-phosphonates using trimethyl (trifluoromethyl) silane
Chu L, et al.
Synthesis, 44(10), 1521-1525 (2012)
Peter T Kaplan et al.
Beilstein journal of organic chemistry, 13, 2297-2303 (2017-11-29)
A number of copper reagents were compared for their effectiveness in trifluoromethylating 4-iodobiphenyl, 4-iodotoluene, and 2-iodotoluene. Yields over time were plotted in order to refine our understanding of each reagent performance, identify any bottlenecks, and provide more insight into the
Stereoselective Nucleophilic Trifluoromethylation of N?(tert?Butylsulfinyl) imines by Using Trimethyl (trifluoromethyl) silane.
Prakash G K, et al.
Angewandte Chemie (International Edition in English), 113(3), 609-610 (2001)
Craig P Johnston et al.
Journal of the American Chemical Society, 140(35), 11112-11124 (2018-08-07)
The mechanism of CF3 transfer from R3SiCF3 (R = Me, Et, iPr) to ketones and aldehydes, initiated by M+X- (<0.004 to 10 mol %), has been investigated by analysis of kinetics (variable-ratio stopped-flow NMR and IR), 13C/2H KIEs, LFER, addition
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