496812
7-烯丙基-7,8-二氢-8-羰基鸟苷
95%
别名:
Loxoribine
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关于此项目
经验公式（希尔记法）:
C13H17N5O6
化学文摘社编号:
分子量:
339.30
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
InChI
1S/C13H17N5O6/c1-2-3-17-6-9(15-12(14)16-10(6)22)18(13(17)23)11-8(21)7(20)5(4-19)24-11/h2,5,7-8,11,19-21H,1,3-4H2,(H3,14,15,16,22)/t5-,7-,8-,11-/m1/s1
SMILES string
NC1=NC2=C(N(CC=C)C(=O)N2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1
InChI key
VDCRFBBZFHHYGT-IOSLPCCCSA-N
assay
95%
optical activity
[α]21/D −32°, c = 1 in H2O
mp
227-230 °C (lit.)
Quality Level
Application
Loxoribine is a selective toll-like receptor 7 (TLR7) agonist that activates immune cells and increases cytokine production.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Yusuke Murakami et al.
Scientific reports, 7, 44042-44042 (2017-03-08)
Toll-like Receptor 9 (TLR9) is an innate immune receptor recognizing microbial DNA. TLR9 is also activated by self-derived DNA, such as mitochondrial DNA, in a variety of inflammatory diseases. We show here that TLR9 activation in vivo is controlled by
Marjorie Robbins et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 15(9), 1663-1669 (2007-06-21)
RNA molecules such as single-stranded RNA (ssRNA) and small interfering RNA (siRNA) duplexes induce Toll-like receptor (TLR)-mediated immune stimulation after intracellular delivery. We have previously shown that selective incorporation of 2'-O-methyl (2'OMe) residues into siRNA abrogates cytokine production without reduction
Kristie A Jenkins et al.
Developmental and comparative immunology, 33(5), 660-667 (2008-12-23)
Although Toll-like receptors (TLRs) have been well characterised in mammals, less work has been carried out in non-mammalian species, such as chickens. In this study the response of chicken cells to the TLR9 subfamily of ligands was characterised in vitro
Joyce E Yu et al.
The Journal of allergy and clinical immunology, 124(2), 349-356 (2009-07-14)
Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia, reduced numbers of peripheral blood isotype-switched memory B cells, and loss of plasma cells. Because Toll-like receptor (TLR) activation of B cells can initiate and potentially sustain normal B cell functions, we
Saradiya Chatterjee et al.
Cancer research, 74(18), 5008-5018 (2014-07-31)
Toll-like receptors (TLR) recognize pathogen molecules and danger-associated signals that stimulate inflammatory processes. TLRs have been studied mainly in antigen-presenting cells, where they exert important immune regulatory functions, but they are also expressed by epithelial tumor cells, where they have
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