2-乙酰基-5-甲基噻吩

2-Acetyl-5-methylthiophene is a volatile organic compound formed during the reaction between L-cysteine and dihydroxyacetone in glycerine or triglyceride solvent system.[1] It can be prepared by reacting 2-methylthiophene with acetic anhydride.[2] 2-Acetyl-5-methylthiophene undergoes palladium-catalyzed cross-coupling reaction with aryl bromides to form C-4 arylated product.[3] It reacts with 1,2-bis(5-formyl-2-methylthiophen-3-yl)cyclopentene via Aldol condensation to form a chalcone with photochromic property.[4] The standard molar enthalpies of combustion, formation and vaporization of 2-acetyl-5-methylthiophene are 4341.9 ± 1.8kJ/mol, 158.0 ± 2.1kJ/mol and 62.0 ± 2.6kJ/mol, respectively.[5]

2-Acetyl-5-methylthiophene may be used in the preparation of:

• 2-ethyl-5-methylthiophene[6]
• (5-methylthiophen-2-yl)glyoxal[7]
• (2E)-1-(5-methylthiophen-2-yl)-3-(pyridin-3-yl)prop-2-en-1-one[8]
• ethyl 3-(5-methylthiophen-2-yl)-3-oxopropanoate[8]