550019
N,N-二甲基亚二丙基三胺
99%
别名:
DMAPAPA
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线性分子式:
(CH3)2N(CH2)3NH(CH2)3NH
化学文摘社编号:
分子量:
159.27
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
234-148-4
MDL number:
Assay:
99%
InChI key
OMKZWUPRGQMQJC-UHFFFAOYSA-N
InChI
1S/C8H21N3/c1-11(2)8-4-7-10-6-3-5-9/h10H,3-9H2,1-2H3
SMILES string
CN(C)CCCNCCCN
assay
99%
refractive index
n20/D 1.4630 (lit.)
bp
220 °C (lit.)
density
0.883 g/mL at 25 °C (lit.)
functional group
amine
Quality Level
General description
N,N-二甲基二丙烯三胺是一种脂肪族无环胺，通常用于开发基因传递的聚合体系。
Application
N,N-二甲基二丙烯三胺（DP）可用于：
- 制备可生物降解的两亲性聚阳离子共聚物聚环氧乙烷-b-聚（3-己内酯-g-DP）[PEO-b-P（CL-g-DP）]。
- 开发第二代氨基糖苷 6′-N-乙酰基转移酶（AAC（6′）抑制剂。
- 制备可用于治疗胰腺癌的亲水性吉西他滨共轭阳离子共聚物。
Legal Information
Arkema Inc. 产品
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Corr. 1A - Skin Sens. 1
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 1
flash_point_f
210.2 °F - closed cup
flash_point_c
99 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Feng Gao et al.
Journal of medicinal chemistry, 49(17), 5273-5281 (2006-08-18)
Truncated aminoglycoside-coenzyme A bisubstrate analogues were efficiently prepared using a convergent approach where the amine and the thiol are coupled in one pot with the addition of a linker, without the need for protecting groups. These derivatives were tested for
Xiao-Bing Xiong et al.
Biomaterials, 30(2), 242-253 (2008-10-08)
The RNA interference (RNAi) technology has been successfully used in elucidating mechanisms behind various biological events. However, in the absence of safe and effective carriers for in vivo delivery of small interfering RNAs (siRNAs), application of this technology for therapeutic
Anupama Mittal et al.
Biomaterials, 35(25), 7077-7087 (2014-05-20)
Clinical effectiveness of gemcitabine in pancreatic cancer is hindered due to its rapid plasma metabolism and development of chemo-resistance. We have previously delineated the significant role of miRNAs in mediating the growth and proliferation of cancer stem cells (CSCs) which
[Toxicity of several aliphatic amines].
G I Sidorin et al.
Gigiena truda i professional'nye zabolevaniia, (11)(11), 50-53 (1984-11-01)
J Shen et al.
Biomaterials, 34(18), 4520-4531 (2013-03-23)
The low toxicity and efficient gene delivery of polymeric vectors remain the major barrier to the clinical application of non-viral gene therapy. Here, we present a poly-D, L-succinimide (PSI)-based biodegradable cationic polymer which mimicked the golden standard, branched polyethylenimine (PEI
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