55100
8-羟基喹啉 半硫酸盐
≥98.0% (dry substance, T), yellow
别名:
8-氢氧化喹啉 半硫酸盐
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关于此项目
经验公式（希尔记法）:
C18H14N2O2 · H2SO4
化学文摘社编号:
分子量:
388.39
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
205-137-1
Beilstein/REAXYS Number:
3760550
MDL number:
Assay:
≥98.0% (dry substance, T)
InChI key
YYVFXSYQSOZCOQ-UHFFFAOYSA-N
InChI
1S/2C9H7NO.H2O4S/c2*11-8-5-1-3-7-4-2-6-10-9(7)8;1-5(2,3)4/h2*1-6,11H;(H2,1,2,3,4)
SMILES string
OS(O)(=O)=O.Oc1cccc2cccnc12.Oc3cccc4cccnc34
description
C9H7NO · ½H2SO4 (Linear Formula)
assay
≥98.0% (dry substance, T)
impurities
~5% water
color
yellow
antibiotic activity spectrum
fungi
mode of action
DNA synthesis | interferes, enzyme | inhibits
General description
化学结构：喹诺酮类
Application
8-羟基喹啉半硫酸盐 (8-OHQ) 可用于制备具有蛋白酶抑制活性的 Cu [8-OHQ] 2。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Kenyon G Daniel et al.
Biochemical pharmacology, 67(6), 1139-1151 (2004-03-10)
Here we report that organic copper complexes can potently and selectively inhibit the chymotrypsin-like activity of the proteasome in vitro and in vivo. Several copper compounds, such as NCI-109268 and bis-8-hydroxyquinoline copper(II) [Cu(8-OHQ)(2)], can inhibit the chymotrypsin-like activity of purified
Erik H J G Aarntzen et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 19(6), 1525-1533 (2013-02-06)
Anticancer dendritic cell (DC) vaccines require the DCs to relocate to lymph nodes (LN) to trigger immune responses. However, these migration rates are typically very poor. Improving the targeting of ex vivo generated DCs to LNs might increase vaccine efficacy
Saverio Tardito et al.
Journal of medicinal chemistry, 55(23), 10448-10459 (2012-11-23)
This study reports the structure-activity relationship of a series of 8-hydroxoquinoline derivatives (8-HQs) and focuses on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) copper complex (Cu(CQ)). 8-HQs alone cause a dose-dependent loss of viability of the human tumor HeLa and
M Škodová et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 13(18), 4244-4250 (2012-11-08)
Improvements in cancer diagnostics and therapy have recently attracted the interest of many different branches of science. This study presents one of the new possible approaches in the diagnostics and therapy of cancer by using polymeric chelates as carriers. Graft
Donald J Messner et al.
Digestive diseases and sciences, 58(7), 1899-1908 (2013-04-06)
Iron overload is associated with increased severity of nonalcoholic fatty liver disease (NAFLD) including progression to nonalcoholic steatohepatitis and hepatocellular carcinoma. To identify potential role(s) of iron in NAFLD, we measured its effects on pathways of oxidative stress and insulin
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