553867
2,4-二氯-5-氟-3-硝基苯甲酸
97%
方案
97%
表单
solid
mp
193-197 °C (lit.)
官能团
carboxylic acid
chloro
fluoro
nitro
SMILES字符串
OC(=O)c1cc(F)c(Cl)c(c1Cl)[N+]([O-])=O
InChI
1S/C7H2Cl2FNO4/c8-4-2(7(12)13)1-3(10)5(9)6(4)11(14)15/h1H,(H,12,13)
InChI key
PCSAPCNEJUEIGU-UHFFFAOYSA-N
一般描述
2,4-Dichloro-5-fluoro-3-nitrobenzoic acid can be prepared from 2,4-dichloro-5-fluorobenzoic acid.
应用
2,4-Dichloro-5-fluoro-3-nitrobenzoic acid may be used to synthesize:
- ethyl 3-(N,N-dimethylamino)-2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)acrylate
- 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
- ethyl-3-(N,N-dimethylamino)-2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl) acrylate
- substituted 4(1H)-oxoquinoline-3-carboxylic acid
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Mohammed H Al-Huniti et al.
Molecules (Basel, Switzerland), 12(8), 1558-1568 (2007-10-26)
Substituted [1,4]thiazepino[2,3-h]quinolinecarboxylic acid 3 is prepared by PPA-catalyzed thermal lactamization of the respective 8-amino-7-[(2-carboxyethyl)thio]-1,4-dihydroquinoline-3-carboxylic acid 9. The latter synthon is obtained by reduction of the 8-nitro-1,4-dihydroquinoline precursor 8 which, in turn, is made accessible via interaction of 3-mercaptopropionic acid with
Yusuf M Al-Hiari et al.
Molecules (Basel, Switzerland), 13(11), 2880-2893 (2008-11-21)
[1,4]Diazepino[2,3-h]quinolone carboxylic acid 3 and its benzo-homolog tetrahydroquino[7,8-b]benzodiazepine-3-carboxylic acid 5 were prepared via PPAcatalyzed thermal lactamization of the respective 8-amino-7-substituted-1,4-dihydroquinoline-3-carboxylic acid derivatives 8, 10. The latter compounds were obtained by reduction of their 8-nitro-7-substituted-1,4-dihydroquinoline-3-carboxylic acid precursors 7, 9 which, in
Synthesis and antibacterial activity of 9-cyclopropyl-4-fluoro-6-oxo-6, 9-dihydro-[1, 2, 5] thiadiazolo [3, 4-h] quinoline-7-carboxylic acid and its ethyl ester.
Al-Qawasmeh RA, et al.
ARKIVOC (Gainesville, FL, United States), 12, 322-326 (2009)
M Engler et al.
Antimicrobial agents and chemotherapy, 42(5), 1151-1159 (1998-05-21)
Photodegradation of sparfloxacin was observed by means of high-pressure liquid chromatography with UV detection and liquid chromatography coupled with UV detection and tandem mass spectrometry (LC-MS/MS). Three products were detected. Comparison with an independently synthesized derivative of sparfloxacin revealed the
Yusuf M Al-Hiari et al.
Journal of enzyme inhibition and medicinal chemistry, 26(5), 649-656 (2011-01-13)
Direct interaction between 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and primary α-amino acids (exemplified by glycine, alanine, and l-valine) in aqueous ethanolic NaHCO(3) at 70-80°C for 24-72 h produced the respective N-(4-oxoquinolin-7-yl)-α-amino acids (6a-c). The latter derivatives underwent reductive lactamization upon treatment with Na(2)S(2)O(4) in
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