567280
4-(3-羟丙基)吗啉
95%
别名:
3-(4-吗啉)-1-丙醇, 3-吗啉代-1-丙醇
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关于此项目
经验公式（希尔记法）:
C7H15NO2
化学文摘社编号:
分子量:
145.20
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
Assay:
95%
InChI
1S/C7H15NO2/c9-5-1-2-8-3-6-10-7-4-8/h9H,1-7H2
SMILES string
OCCCN1CCOCC1
InChI key
VZKSLWJLGAGPIU-UHFFFAOYSA-N
assay
95%
impurities
may contain ~5% morpholine
refractive index
n20/D 1.4770 (lit.)
bp
240-241 °C (lit.)
density
1.049 g/mL at 25 °C (lit.)
Application
4-(3-Hydroxypropyl)morpholine may be used in the synthesis of macrocyclic urea compounds, which can act as potent Chk1 inhibitors.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Repr. 2 - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
185.0 °F - closed cup
flash_point_c
85 °C - closed cup
法规信息
新产品
此项目有
"Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors"
Li J, et al.
Bioorganic & Medicinal Chemistry Letters, 17(23), 6499-6504 (2007)
David Johansson et al.
BMC cancer, 9, 67-67 (2009-02-28)
The prerequisite for the potential use of the bacterial toxin verotoxin-1 in the treatment of breast cancer was investigated by first determining the expression of its receptor Gb3 (CD77) in clinical breast cancer tissue specimens. We then examined the cytotoxicity
Y Jiang et al.
Journal of biological regulators and homeostatic agents, 34(6), 2029-2036 (2020-12-12)
Dysregulation of the adipo-osteogenic differentiation balance of mesenchymal stem cells (MSCs), which are common progenitor cells of adipocytes and osteoblasts, has been associated with many pathophysiologic diseases, such as obesity, osteopenia, and several neurodegenerative disorders. Growing evidence suggests that lipid
Weihong Xu et al.
Biochemical and biophysical research communications, 463(4), 545-550 (2015-06-01)
In the current study, we investigated the potential activity of AR-42, a novel histone deacetylase (HDAC) inhibitor, against colon cancer cells. Our in vitro results showed that AR-42 induced ceramide production, exerted potent anti-proliferative and pro-apoptotic activities in established (SW-620 and
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