570907
(S,S,S)-2-氮杂双环[3.3.0]辛烷-3-羧酸苄酯盐酸盐
97%
别名:
(S,S,S)-2-氮杂双环[3,3,0]辛烷羧酸苄酯 盐酸盐, (S,S,S)-2-氮杂双环[3,3,0]辛烷-3-羧酸苄酯 盐酸盐
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关于此项目
经验公式（希尔记法）:
C15H19NO2 ·HCl
化学文摘社编号:
分子量:
281.78
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
方案
97%
旋光性
[α]20/D -26°, c = 1% in DMSO
mp
176-180 °C (lit.)
官能团
ester
phenyl
SMILES字符串
Cl[H].[H][C@@]12CCC[C@]1([H])N[C@@H](C2)C(=O)OCc3ccccc3
InChI
1S/C15H19NO2.ClH/c17-15(18-10-11-5-2-1-3-6-11)14-9-12-7-4-8-13(12)16-14;/h1-3,5-6,12-14,16H,4,7-10H2;1H/t12-,13-,14-;/m0./s1
InChI key
HLXCXOQXUDRJLF-JKBZPBJLSA-N
应用
Benzyl (S,S,S)-2-azabicyclo[3.3.0]octane-3-carboxylate hydrochloride can be used:
- In the preparation of ramipril, an angiotensin-converting enzyme (ACE) inhibitor.
- As a starting material for the synthesis of octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as potent DPP4 inhibitors.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Xun Ji et al.
European journal of medicinal chemistry, 86, 242-256 (2014-08-29)
Based on the previous work in our group and the principle of computer-aided drug design, a series of novel β-amino pyrrole-2-carbonitrile derivatives was designed and synthesized. Compounds 8l and 9l were efficacious and selective DPP4 inhibitors resulting in decreased blood
Expeditious synthesis of Ramipril: an Angiotensin-converting enzyme (ACE) inhibitor
Malakondaiah GC, et al.
Synthetic Communications, 38(11), 1737-1744 (2008)
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