57410
吲哚-3-丙酸
≥97.0% (T)
别名:
NSC 3252, NSC 47831, 3-（3-吲哚基）丙酸, IPA
质量水平
方案
≥97.0% (T)
表单
solid
官能团
carboxylic acid
SMILES字符串
OC(=O)CCc1c[nH]c2ccccc12
InChI
1S/C11H11NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6H2,(H,13,14)
InChI key
GOLXRNDWAUTYKT-UHFFFAOYSA-N
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一般描述
吲哚-3-丙酸可以通过脱氨反应从色氨酸获得。
应用
反应物用于制备：
- 独脚金内酯的荧光类似物
- 抗肿瘤剂
- 黑皮质素受体配体
- 免疫抑制剂
- 丙肝病毒抑制剂
- 组胺H4受体激动剂
- NR2B/NMDA受体拮抗剂
- 治疗肥胖的 CB1 拮抗剂
- 抗细菌剂
- TGF-β受体结合抑制剂
生化/生理作用
被研究作为改善肝移植后灌注的辅助手段。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Wanguo Wei et al.
Bioorganic & medicinal chemistry letters, 19(24), 6926-6930 (2009-11-10)
New small molecule inhibitors of HCV were discovered by screening a small library of indoline alkaloid-type compounds. An automated assay format was employed which allowed identification of dimerization inhibitors of core, the capsid protein of the virus. These compounds were
Design and parallel synthesis of new bicyclic small molecules for targeting the melanocortin receptors.
Byoung J Min et al.
Advances in experimental medicine and biology, 611, 187-188 (2009-04-30)
Prandi, C.; et al.
European Journal of Organic Chemistry, 3781-3781 (2011)
Subra, G.; et al.
QSAR & Combinatorial Science, 26, 496-496 (2007)
Rosaria Gitto et al.
Bioorganic & medicinal chemistry, 17(4), 1640-1647 (2009-01-23)
A combined ligand-based and structure-based approach has previously allowed us to identify NR2B/NMDA receptor antagonists containing indole scaffold. In order to further explore the main structure activity relationships of this class of derivatives we herein report the design, synthesis and
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