642002
(3S,5R,8aS)-(+)-六氢-3-苯基-5H-噁唑并[3,2-a]吡啶-5-甲腈
97%
别名:
(+)-2-氰基-6-苯基噁唑哌啶, [3S-(3α,5β,8aβ)]-六氢-3-苯基-5H-噁唑并[3,2-a]吡啶-5-甲腈
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关于此项目
经验公式（希尔记法）:
C14H16N2O
化学文摘社编号:
分子量:
228.29
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
InChI
1S/C14H16N2O/c15-9-12-7-4-8-14-16(12)13(10-17-14)11-5-2-1-3-6-11/h1-3,5-6,12-14H,4,7-8,10H2/t12-,13-,14+/m1/s1
SMILES string
[H][C@]12CCC[C@H](C#N)N1[C@H](CO2)c3ccccc3
InChI key
GQHMNZGZXHZLEN-MCIONIFRSA-N
assay
97%
form
solid
mp
79-83 °C (lit.)
Application
(3S,5R,8aS)-(+)-Hexahydro-3-phenyl-5H-oxazolo[3,2-a]pyridine-5-carbonitrile can be used as a starting material:
- To prepare spirocyclic aminochroman derivatives as possible 5-HT1A agonists.
- In the asymmetric synthesis of aza-analogs of podophyllotoxin as potent antitumor agents.
Asymmetric synthesis XXVIII: Hydroxylated benzoquinolizidine analogues of podophyllotoxin via the (CN (R, S) method.
Lienard P, et al.
Tetrahedron, 49(19), 3995-4006 (1993)
Enantioselective synthesis of spirocyclic aminochroman derivatives according to the CN (R, S) strategy
Pave G, et al.
The Journal of Organic Chemistry, 68(4), 1401-1408 (2003)
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