方案
97%
表单
solid
mp
236-240 °C (lit.)
官能团
carboxylic acid
SMILES字符串
Cc1cc([nH]n1)C(O)=O
InChI
1S/C5H6N2O2/c1-3-2-4(5(8)9)7-6-3/h2H,1H3,(H,6,7)(H,8,9)
InChI key
WSMQKESQZFQMFW-UHFFFAOYSA-N
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一般描述
3-Methylpyrazole-5-carboxylic acid is a potent and selective D-amino acid oxidase (DAO) (also known as DAAO, DAMOX and OXDA) inhibitor that protects DAO cells from oxidative stress induced by D-Serine. 3-Methylpyrazole-5-carboxylic acid specifically prevents formalin-induced tonic pain.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Tiziana Adage et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 18(3), 200-214 (2007-08-08)
Non-competitive N-methyl-d-aspartate (NMDA) blockers induce schizophrenic-like behavior in healthy volunteers and exacerbate symptomatology in schizophrenic patients. Hence, a compound able to enhance NMDA neurotransmission by increasing levels of d-serine, an endogenous full agonist at the glycine site of the NMDA
A McAllister et al.
Biochemical pharmacology, 31(1), 63-68 (1982-01-01)
The administration of the antilipolytic agents sodium nicotinate (1 mmole/kg i.p.) or sodium 5-methylpyrazole-3-carboxylate (0.5 or 1.0 mmole/kg i.p.) to alloxan-diabetic rats produced a significant reduction in the plasma concentration of free fatty acids and a slight reduction in blood
Michael Williams
Biochemical pharmacology, 78(11), 1360-1365 (2009-07-14)
Antipsychotics, the drugs used currently for the treatment of schizophrenia, produce their therapeutic effects via the blockade of dopamine receptors. These compounds are, however, limited in their therapeutic efficacy and have side effect liabilities that also limit their use. Agents
In vitro effects of theophylline on insulin receptors in adipocytes: correlation with the lipolytic action of the agent.
H J Steinfelder et al.
Biochemical and biophysical research communications, 104(1), 45-51 (1982-01-15)
M J Holness et al.
The Biochemical journal, 241(2), 421-425 (1987-01-15)
The work investigated the mechanisms for modulation of renal and hepatic pyruvate dehydrogenase complex (PDH) activities after carbohydrate re-feeding of 48 h-starved rats, and identified a regulatory role for tri-iodothyronine. Glucose re-feeding decreased blood concentrations of lipid fuels in both
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