653152
4-巯基苯基乙酸
97%
别名:
2-（4-巯基苯基）乙酸, 4-巯基苯基乙酸, 对巯基苯乙酸, （4-巯基苯基）乙酸, （4-羧甲基）苯硫酚
登录查看公司和协议定价
选择尺寸
关于此项目
线性分子式:
HSC6H4CH2CO2H
化学文摘社编号:
分子量:
168.21
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
方案
97%
表单
solid
mp
105-109 °C (lit.)
官能团
carboxylic acid
储存温度
2-8°C
SMILES字符串
OC(=O)Cc1ccc(S)cc1
InChI
1S/C8H8O2S/c9-8(10)5-6-1-3-7(11)4-2-6/h1-4,11H,5H2,(H,9,10)
InChI key
ORXSLDYRYTVAPC-UHFFFAOYSA-N
一般描述
4-巯基苯基乙酸(MPAA)是一种硫醇添加剂，广泛应用于自然化学偶联（NCL）反应，用于肽片段的选择性高效偶联。
应用
4-巯基苯基乙酸用于通过序列自然化学连接由双（2-磺酰乙基）氨基肽制备小泛素修饰肽。
可用于：
可用于：
- 树脂制备肽-α噻吩基酯，以在化学连接过程中化学合成多肽。
- 在一锅法中，采用天然化学连接和/或脱硫法去保护（乙酰胺基-甲基）半胱氨酸来制备多肽。
- 钯通过天然化学连接法促进N-端半胱氨酸去保护，以制备合成挑战性蛋白。
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Jonas E Jensen et al.
Marine drugs, 10(7), 1511-1527 (2012-08-02)
APETx2 is a peptide isolated from the sea anemone Anthopleura elegantissima. It is the most potent and selective inhibitor of acid-sensing ion channel 3 (ASIC3) and it is currently in preclinical studies as a novel analgesic for the treatment of
Daniel J Capon et al.
Proceedings of the Japan Academy. Series B, Physical and biological sciences, 87(9), 603-616 (2011-11-15)
There is a significant need for antibodies that can bind targets with greater affinity. Here we describe a novel strategy employing chemical semisynthesis to produce symmetroadhesins: antibody-like molecules having nonprotein hinge regions that are more flexible and extendible and are
Direct on-resin synthesis of peptide-αthiophenylesters for use in native chemical ligation
Bang D, et al.
Organic Letters, 8(6), 1049-1052 (2006)
Efficient palladium-assisted one-pot deprotection of (acetamidomethyl) cysteine following native chemical ligation and/or desulfurization to expedite chemical protein synthesis
Maity SK, et al.
Angewandte Chemie (International Edition in English), 55(28), 8108-8112 (2016)
Sunithi Gunasekera et al.
Frontiers in microbiology, 11, 168-168 (2020-03-11)
Can antimicrobial activity and peptide stability of alpha-helical peptides be increased by making them into dimers and macrocycles? Here, we explore that concept by using KR-12 as the starting point for peptide engineering. KR-12 has previously been determined as the
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持