654280
1-(苯基磺酰)-3-吲哚基硼酸频哪醇酯
97%
别名:
1-(苯磺酰基)-3-吲哚硼酸频哪醇酯
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关于此项目
经验公式（希尔记法）:
C20H22BNO4S
化学文摘社编号:
分子量:
383.27
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352103
MDL number:
产品名称
1-(苯基磺酰)-3-吲哚基硼酸频哪醇酯, 97%
InChI
1S/C20H22BNO4S/c1-19(2)20(3,4)26-21(25-19)17-14-22(18-13-9-8-12-16(17)18)27(23,24)15-10-6-5-7-11-15/h5-14H,1-4H3
SMILES string
CC1(C)OB(OC1(C)C)c2cn(c3ccccc23)S(=O)(=O)c4ccccc4
InChI key
OMZLHWZHHPAZPW-UHFFFAOYSA-N
assay
97%
form
solid
mp
120-125 °C
Quality Level
Application
1-(Phenylsulfonyl)-3-indolylboronic acid pinacol ester can be used:
- In one or two key synthetic steps for the preparation of a key intermediate of lycogarubin C.
- To prepare 3-(4,5-dibromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-1-(phenylsulfonyl)-1H-indole, a key intermediate for the synthesis of tubulin inhibitor VERU-111 analogs.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Qinghui Wang et al.
Journal of medicinal chemistry, 61(17), 7877-7891 (2018-08-21)
Colchicine binding site inhibitors (CBSIs) hold great potential in developing new generations of antimitotic drugs. Unlike existing tubulin inhibitors such as paclitaxel, they are generally much less susceptible to resistance caused by the overexpression of drug efflux pumps. The 3,4,5-trimethoxyphenyl
John T Gupton et al.
Tetrahedron, 70(52), 9759-9767 (2015-01-15)
Lycogarubin C, permethyl storniamide A and lamellarin G trimethyl ether are pyrrole containing, natural products, which exhibit interesting biological properties. Such properties include anti-tumor activity on a variety of cancer cell lines including those that confer drug resistance, inhibition of
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