656356
(R)-(-)-3-哌啶甲酸
97%
别名:
(R)-(–)-甲酸哌啶
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关于此项目
经验公式（希尔记法）:
C6H11NO2
化学文摘社编号:
分子量:
129.16
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
产品名称
(R)-(-)-3-哌啶甲酸, 97%
InChI key
XJLSEXAGTJCILF-RXMQYKEDSA-N
SMILES string
OC(=O)[C@@H]1CCCNC1
InChI
1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9)/t5-/m1/s1
assay
97%
form
solid
optical activity
[α]22/D −5°, c = 1 in H2O
mp
251-255 °C
application(s)
peptide synthesis
functional group
carboxylic acid
Quality Level
Gene Information
human ... SLC6A1(6529), SLC6A11(6538), SLC6A12(6539)
mouse ... Slc6a1(232333)
rat ... Slc6a1(79212), Slc6a12(50676)
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General description
(R)-(-)-3-Piperidinecarboxylic acid is an inhibitor of GABA (γ-aminobutyric acid) uptake.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Joanna R Dodd et al.
The Journal of biological chemistry, 282(21), 15528-15533 (2007-04-03)
The creatine transporter (CRT) is a member of a large family of sodium-dependent neurotransmitter and amino acid transporters. The CRT is closely related to the gamma-aminobutyric acid (GABA) transporter, GAT-1, yet GABA is not an effective substrate for the CRT.
Michael P DeNinno et al.
Bioorganic & medicinal chemistry letters, 21(10), 3095-3098 (2011-04-05)
The first highly potent and selective PDE8 inhibitors are disclosed. The initial tetrahydroisoquinoline hit was transformed into a nipecotic amide series in order to address a reactive metabolite issue. Reduction of lipophilicity to address metabolic liabilities uncovered an interesting diastereomer-dependent
Philip M Duy et al.
Experimental physiology, 95(7), 774-787 (2010-04-27)
Hyperthermic prolongation of the laryngeal chemoreflex (LCR) in decerebrate piglets is prevented or reversed by GABA(A) receptor antagonists and adenosine A(2A) (Ad-A(2A)) receptor antagonists administered in the nucleus of the solitary tract (NTS). Therefore, we tested the hypothesis that enhanced
Hong Gao et al.
Neuropharmacology, 58(8), 1220-1227 (2010-03-17)
Zolpidem is a widely prescribed sleep aid with relative selectivity for GABA(A) receptors containing alpha1-3 subunits. We examined the effects of zolpidem on the inhibitory currents mediated by GABA(A) receptors using whole-cell patch-clamp recordings from DMV neurons in transverse brainstem
Khashayar Nassery et al.
Archives of oral biology, 52(7), 607-613 (2007-02-06)
The purpose of this study was to determine whether (a) an uptake system for gamma-aminobutyric acid (GABA) exists in human dental pulp, (b) GABA can be released from nerves in this tissue, and (c) GABA(B) autoreceptors modulate release of this
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