667005
(R)-(+)-3,3,3-三氟-1,2-环氧丙烷
97%
别名:
(R)-(+)-2-三氟甲基环氧乙烷
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关于此项目
经验公式（希尔记法）:
C3H3F3O
化学文摘社编号:
分子量:
112.05
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
NACRES:
NA.22
质量水平
方案
97%
折射率
n20/D <1.300
沸点
25-32 °C
密度
1.294 g/mL at 25 °C
官能团
ether
fluoro
储存温度
2-8°C
SMILES字符串
FC(F)(F)[C@H]1CO1
InChI
1S/C3H3F3O/c4-3(5,6)2-1-7-2/h2H,1H2/t2-/m1/s1
InChI key
AQZRARFZZMGLHL-UWTATZPHSA-N
应用
(R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane can be used as a substrate to synthesize:
- Substituted trifluoro amino propanols, which are found to be potent inhibitors of cholesteryl ester transfer protein.
- (2R) Trifluoro-(methoxybenzyloxy)-propanol (chiral glycol) by reacting with 4-methoxybenzyl alcohol in the presence of NaH. Chiral glycol intermediate is further utilized for the preparation of trifluoromethyl glycol carbamates as potential monoacylglycerol lipase (MAGL) inhibitors.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Flam. Liq. 1
储存分类代码
3 - Flammable liquids
WGK
WGK 3
闪点(°F)
-14.8 °F
闪点(°C)
-26 °C
个人防护装备
Eyeshields, Faceshields, Gloves
法规信息
危险化学品
此项目有
Discovery of trifluoromethyl glycol carbamates as potent and selective covalent monoacylglycerol lipase (MAGL) inhibitors for treatment of neuroinflammation
McAllister LA, et al.
Journal of Medicinal Chemistry, 61(7), 3008-3026 (2018)
Discovery of a simple picomolar inhibitor of cholesteryl ester transfer protein
Reinhard EJ, et al.
Journal of Medicinal Chemistry, 46(11), 2152-2168 (2003)
Emily J Reinhard et al.
Journal of medicinal chemistry, 46(11), 2152-2168 (2003-05-16)
A novel series of substituted N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)-trifluoro-3-amino-2-propanols is described which potently and reversibly inhibit cholesteryl ester transfer protein (CETP). Starting from the initial lead 1, various substituents were introduced into the 3-phenoxyaniline group to optimize the relative activity for inhibition of
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