667005
(R)-(+)-3,3,3-三氟-1,2-环氧丙烷
97%
别名:
(R)-(+)-2-三氟甲基环氧乙烷
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关于此项目
经验公式（希尔记法）:
C3H3F3O
化学文摘社编号:
分子量:
112.05
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
Assay:
97%
InChI
1S/C3H3F3O/c4-3(5,6)2-1-7-2/h2H,1H2/t2-/m1/s1
SMILES string
FC(F)(F)[C@H]1CO1
InChI key
AQZRARFZZMGLHL-UWTATZPHSA-N
assay
97%
refractive index
n20/D <1.300
bp
25-32 °C
density
1.294 g/mL at 25 °C
functional group
ether, fluoro
storage temp.
2-8°C
Quality Level
Application
(R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane can be used as a substrate to synthesize:
- Substituted trifluoro amino propanols, which are found to be potent inhibitors of cholesteryl ester transfer protein.
- (2R) Trifluoro-(methoxybenzyloxy)-propanol (chiral glycol) by reacting with 4-methoxybenzyl alcohol in the presence of NaH. Chiral glycol intermediate is further utilized for the preparation of trifluoromethyl glycol carbamates as potential monoacylglycerol lipase (MAGL) inhibitors.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Flam. Liq. 1
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
-14.8 °F
flash_point_c
-26 °C
ppe
Eyeshields, Faceshields, Gloves
法规信息
危险化学品
此项目有
Discovery of trifluoromethyl glycol carbamates as potent and selective covalent monoacylglycerol lipase (MAGL) inhibitors for treatment of neuroinflammation
McAllister LA, et al.
Journal of Medicinal Chemistry, 61(7), 3008-3026 (2018)
Discovery of a simple picomolar inhibitor of cholesteryl ester transfer protein
Reinhard EJ, et al.
Journal of Medicinal Chemistry, 46(11), 2152-2168 (2003)
Emily J Reinhard et al.
Journal of medicinal chemistry, 46(11), 2152-2168 (2003-05-16)
A novel series of substituted N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)-trifluoro-3-amino-2-propanols is described which potently and reversibly inhibit cholesteryl ester transfer protein (CETP). Starting from the initial lead 1, various substituents were introduced into the 3-phenoxyaniline group to optimize the relative activity for inhibition of
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