673927
N-Boc-4-甲基-4-哌啶甲酸乙酯
97%
别名:
1-tert-Butoxycarbonyl-4-methylpiperidine-4-carboxylic acid ethyl ester, 4-Methyl-1,4-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 4-ethyl ester
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关于此项目
经验公式（希尔记法）:
C14H25NO4
化学文摘社编号:
分子量:
271.35
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
方案
97%
折射率
n20/D 1.4554
密度
1.0134 g/mL at 25 °C
SMILES字符串
CCOC(=O)C1(C)CCN(CC1)C(=O)OC(C)(C)C
InChI
1S/C14H25NO4/c1-6-18-11(16)14(5)7-9-15(10-8-14)12(17)19-13(2,3)4/h6-10H2,1-5H3
InChI key
ZQZVWDXMUCTNRI-UHFFFAOYSA-N
应用
将酯官能团替换为氨基官能团，为哌嗪基 CCR5 拮抗剂提供关键的结构单元。
Reactant for synthesis of:
- Dipeptidyl peptidase-4 inhibitor ABT-279
- Building blocks for piperazine-based CCR5 antagonists
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
>230.0 °F
闪点(°C)
> 110 °C
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
Xiao-Hua Jiang et al.
Bioorganic & medicinal chemistry letters, 14(14), 3675-3678 (2004-06-19)
4-Substituted-4-aminopiperidine is an interesting structural motif found in a number of bioactive compounds. An efficient and convenient method for the synthesis of 4-differently substituted-4-aminopiperidine derivatives was described, employing isonipecotate as a starting material and Curtius rearrangement as a key step.
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