690694
α-甲基-L-苯丙氨酸
purum, ≥97.5% (HPLC), ≥97.0% (HPLC)
别名:
α-Me-Phe-OH, (S)-(-)-2-氨基-2-甲基-3-苯基丙酸
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关于此项目
经验公式（希尔记法）:
C10H13NO2
化学文摘社编号:
分子量:
179.22
Beilstein:
4668990
MDL编号:
UNSPSC代码:
12352200
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.22
等级
purum
方案
≥97.0% (HPLC)
≥97.5% (HPLC)
反应适用性
reaction type: solution phase peptide synthesis
应用
peptide synthesis
SMILES字符串
C[C@](N)(Cc1ccccc1)C(O)=O
InChI
1S/C10H13NO2/c1-10(11,9(12)13)7-8-5-3-2-4-6-8/h2-6H,7,11H2,1H3,(H,12,13)/t10-/m0/s1
InChI key
HYOWVAAEQCNGLE-JTQLQIEISA-N
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
C A Brass et al.
The Biochemical journal, 208(3), 765-771 (1982-12-15)
Hyperphenylalaninaemia induced by daily injections of alpha-methylphenylalanine plus phenylalanine caused 20-40% decreases in cerebral dopamine (3,4-dihydroxyphenethylamine) and noradrenaline in 7- and 11-day-old rats. alpha-Methylphenylalanine alone as well as phenylalanine alone caused cerebral dopamine depletion. However, the effects were not additive
C Toniolo et al.
Peptide research, 5(1), 56-61 (1992-01-01)
We have synthesized, by solution methods, and fully characterized a variety of (alpha Me)Phe derivatives and model peptides (to the pentapeptide level). The results of the solution conformational analysis, performed by using infrared absorption and 1H nuclear magnetic resonance, support
M Castillo et al.
Neurochemical research, 13(6), 547-550 (1988-06-01)
Supplementation of 5% phenylalanine plus 0.4% alpha-methylphenylalanine to the standard diet or 1% phenylalanine plus 0.08% alpha-methylphenylalanine to the drinking water produced phenylketonuria-like conditions in 5-day-old chicks. An increase of 10 to 15-fold in the phenylalanine content was observed in
Adverse effects of excessive consumption of amino acids.
N J Benevenga et al.
Annual review of nutrition, 4, 157-181 (1984-01-01)
Shinya Oishi et al.
Journal of medicinal chemistry, 48(3), 764-772 (2005-02-04)
Previous work has shown that incorporation of either 1-aminocyclohexanecarboxylic acid (Ac6c) or alpha-methyl-p-phosphonophenylalanine ((alpha-Me)Ppp) in the phosphotyrosyl (pTyr) C-proximal position (pY + 1 residue) of Grb2 SH2 domain binding peptides confers high affinity. The tetralin-based (S)-2-amino-6-phosphonotetralin-2-carboxylic acid (Atc(6-PO3H2)) simultaneously presents
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