696420
(R)-3-哌啶甲酸乙酯
97%
别名:
(R)-(-)-哌啶-3-羧酸乙酯
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关于此项目
经验公式（希尔记法）:
C8H15NO2
化学文摘社编号:
分子量:
157.21
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
97%
Form:
liquid
InChI
1S/C8H15NO2/c1-2-11-8(10)7-4-3-5-9-6-7/h7,9H,2-6H2,1H3/t7-/m1/s1
SMILES string
CCOC(=O)[C@@H]1CCCNC1
InChI key
XIWBSOUNZWSFKU-SSDOTTSWSA-N
assay
97%
form
liquid
density
1.092 g/mL at 25 °C
Application
Reactant for synthesis of:
Reactant for stereocontrolled hydoiodination of alkynes
Used for an orally potent anti-anxiety drug
- DPP-4 inhibitors
- Dual H1/5-HT2A receptor antagonists for treatment of sleep disorders
- Serotonin and noradrenaline reuptake inhibitors
- GABA uptake inhibitors
Reactant for stereocontrolled hydoiodination of alkynes
Used for an orally potent anti-anxiety drug
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
219.2 °F
flash_point_c
104 °C
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
S H Zorn et al.
The Journal of pharmacology and experimental therapeutics, 242(1), 173-178 (1987-07-01)
Previous reports have suggested that the ethyl ester of (R)-nipecotic acid ethyl ester [(R)-NAEE] displays cholinomimetic properties in vivo. The present study was undertaken to characterize more fully this action by examining the effects of (R)-NAEE in a number of
T Andree et al.
Life sciences, 32(19), 2265-2272 (1983-05-09)
THIP (4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridone-3-ol), a direct acting GABA receptor agonist, has been shown to have antinociceptive properties. To determine whether tolerance develops to the analgesic response, mice received multiple injections of THIP for up to 21 days after which analgesia
M Potegal
Psychopharmacology, 89(4), 444-448 (1986-01-01)
The GABA uptake inhibitor ethyl (R,S)-nipecotate produces a dose-dependent suppression of aggression in highly aggressive hamsters but not in minimally aggressive ones. This suppression occurs at doses below those producing peripheral cholinergic effects; at the highest dose used it persists
A M Rustum et al.
Journal of pharmaceutical and biomedical analysis, 17(8), 1439-1447 (1998-11-04)
Chiral HPLC methods were developed and validated for tiagabine.HCl and its two chiral precursors to determine the chiral purity of the three compounds to ensure the quality of the final product which is used as a new antiepileptic drug. Tiagabine.HCl
Jia-Hua Hu et al.
Journal of neuroscience research, 73(4), 565-572 (2003-08-05)
The present study focused on the involvement of gamma-aminobutyric acid transporter I (GAT1) in pain. We found that GABA uptake was increased in mouse spinal cord at 20 min and 120 min after formalin injection and in mouse brain at
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