705284
1,1′-羰基二咪唑 溶液
0.4 M in methylene chloride
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关于此项目
经验公式（希尔记法）:
C7H6N4O
化学文摘社编号:
分子量:
162.15
UNSPSC Code:
12352115
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
6826
InChI
1S/C7H6N4O/c12-7(10-3-1-8-5-10)11-4-2-9-6-11/h1-6H
SMILES string
O=C(n1ccnc1)n2ccnc2
InChI key
PFKFTWBEEFSNDU-UHFFFAOYSA-N
form
liquid
concentration
0.4 M in methylene chloride
refractive index
n20/D 1.434
density
1.303 g/mL at 25 °C
General description
1,1′-Carbonyldiimidazole (N,N′-carbonyldiimidazole) is a versatile peptide-forming reagent.
Application
1,1′-Carbonyldiimidazole (N,N′-carbonyldiimidazole) may be used in the following studies:
- Synthesis of peptides in aqueous solution.
- Synthesis of isoleucine-5 angiotensin II amide-1.
- For the activation of the hydroxyl termini of tween toward nucleophilic addition.
- As coupling reagent for the coupling of prostaglandins and other carboxylic acids to the amino groups of bovine serum albumin.
- Synthesis of peptide thioesters.
signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
target_organs
Central nervous system
存储类别
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
N,N'-carbonyldiimidazole as coupling reagent for the preparation of bovine serum albumin conjugates.
U Axen
Prostaglandins, 5(1), 45-47 (1974-01-10)
Robert J Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(9), 4984-4989 (2003-04-17)
Novel nanomaterials for bioassay applications represent a rapidly progressing field of nanotechnology and nanobiotechnology. Here, we present an exploration of single-walled carbon nanotubes as a platform for investigating surface-protein and protein-protein binding and developing highly specific electronic biomolecule detectors. Nonspecific
N, N'-Carbonyldiimidazole in Peptide Synthesis. III. 1 A Synthesis of Isoleucine-5 Angiotensin II Amide-I.
Paul R and Anderson GW.
The Journal of Organic Chemistry, 27(6), 2094-2099 (1962)
Zain Kassam et al.
Inflammatory bowel diseases, 20(12), 2483-2492 (2014-09-05)
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC) is perceived to harbor significant morbidity but limited excess mortality, thought to be driven by colon cancer, compared with the general population. Recent studies suggest mortality rates seem
N,N'-carbonyldiimidazole-induced peptide formation in aqueous solution.
K W Ehler et al.
Biochimica et biophysica acta, 434(1), 233-243 (1976-05-20)
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