706531
N-Boc-1,2,3,6-四氢吡啶-4-硼酸频哪醇酯
95%
别名:
(N-叔丁氧羰基)-1,2,3,6-四氢吡啶-4-硼酸频哪醇酯
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关于此项目
经验公式（希尔记法）:
C16H28BNO4
CAS Number:
分子量:
309.21
MDL编号:
UNSPSC代码:
12352103
PubChem化学物质编号:
NACRES:
NA.22
质量水平
方案
95%
表单
powder
mp
100-114 °C
SMILES字符串
CC(C)(C)OC(=O)N1CCC(=CC1)B2OC(C)(C)C(C)(C)O2
InChI
1S/C16H28BNO4/c1-14(2,3)20-13(19)18-10-8-12(9-11-18)17-21-15(4,5)16(6,7)22-17/h8H,9-11H2,1-7H3
InChI key
VVDCRJGWILREQH-UHFFFAOYSA-N
一般描述
Boc-THP-Bpin is frequently used in metal catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Negishi couplings.
应用
Reagent used for
Reagent used in Preparation of several enzymatic inhibitors and receptor ligands
- Suzuki-Miyaura cross-coupling using palladium phosphine catalyst
- Palladium-catalyzed ligand-controlled regioselective Suzuki coupling
- Palladium-catalyzed Suzuki-Miyaura coupling
- Suzuki coupling followed by iodolactonization reaction
- Wrenchnolol derivative optimized for gene activation in cells
Reagent used in Preparation of several enzymatic inhibitors and receptor ligands
- Orally active anaplastic lymphoma kinase inhibitors
- Oxazolecarboxamides as diacylglycerol acyltransferase-1 inhibitors for treatment of obesity and diabetes
- 4-arylpiperidinyl amides and N-arylpiperidin-3-yl-cyclopropanecarboxamides as novel melatonin receptor ligands
- Quinazoline analogs as glucocerebrosidase inhibitors with chaperone activity for treatment of Gaucher disease, a lysosomal storage disorder
- Arylpiperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperidin-3-yl-cyclopropanecarboxamide derivatives as novel melatonin receptor ligands
Li, G.; et al.
Bioorganic & Medicinal Chemistry, 21, 1236-1242 (2011)
Paul M Wehn et al.
Organic letters, 11(24), 5666-5669 (2009-12-17)
A novel approach to the synthesis of substituted 5-amino- and 3-amino-1,2,4-thiadiazoles beginning from a common precursor has been achieved. Derivatization by palladium-catalyzed Suzuki-Miyaura coupling enables the rapid preparation of analogs around this pharmaceutically relevant core. FMO calculations rationalize the observed
Neil A Strotman et al.
The Journal of organic chemistry, 75(5), 1733-1739 (2010-02-10)
Various dihaloazoles can be monoarylated at a single C-X bond with high selectivity via Suzuki coupling. By changing the palladium catalyst employed, the selectivity can be switched for some dihaloazoles, allowing for Suzuki coupling at the other, traditionally less reactive
Dongju Jung et al.
Journal of the American Chemical Society, 131(13), 4774-4782 (2009-03-18)
Naturally occurring transcription factors usually have two independent domains, a DNA-binding domain and an activation domain. In designing a synthetic small molecule that mimics a transcription factor, each of the two domains needs to be replaced by small-molecule counterparts. Results
Juan J Marugan et al.
Journal of medicinal chemistry, 54(4), 1033-1058 (2011-01-22)
Gaucher disease is a lysosomal storage disorder (LSD) caused by deficiency in the enzyme glucocerebrosidase (GC). Small molecule chaperones of protein folding and translocation have been proposed as a promising therapeutic approach to this LSD. Most small molecule chaperones described
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