InChI
1S/C3H4O2/c4-3-1-5-2-3/h1-2H2
SMILES string
O=C1COC1
InChI key
ROADCYAOHVSOLQ-UHFFFAOYSA-N
form
liquid
availability
not available in EU
refractive index
n20/D 1.426
density
1.124 g/mL at 25 °C
functional group
ether
ketone
storage temp.
−20°C
Quality Level
Application
3-氧杂环丁酮可用于合成：
- 各种具有改善的溶解度和降低的亲脂性和两亲性的含氧杂环丁烷铅化合物。
- 与伯酰胺和硫代酰胺通过一步微波介导反应分别生成（羟甲基）恶唑和（羟甲基）噻唑。
- 与α-氨基酸或仲α氨基酸通过热1,3-偶极环加成反应生成含氧杂环丁烷的螺环化合物。
General description
产品在储存期间可能随时间发生聚合。
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
79.0 °F - closed cup
flash_point_c
26.1 °C - closed cup
法规信息
危险化学品
此项目有
Emily M Wright et al.
The journal of physical chemistry. A, 119(29), 7966-7972 (2015-06-25)
The pyrolysis products of gas-phase 3-oxetanone were identified via matrix-isolation Fourier transform infrared spectroscopy and photoionization mass spectrometry. Pyrolysis was conducted in a hyperthermal nozzle at temperatures from 100 to 1200 °C with the dissociation onset observed at ∼600 °C.
Oxetanes as promising modules in drug discovery
Wuitschik G, et al.
Angewandte Chemie (International Edition in English), 45(46), 7736-7739 (2006)
Single-Step Microwave-Mediated Synthesis of Oxazoles and Thiazoles from 3-Oxetanone: A Synthetic and Computational Study
Orr D, et al.
Chemistry?A European Journal , 19(29), 9655-9662 (2013)
Synthesis of oxetane/azetidine containing spirocycles via the 1, 3-dipolar cycloaddition reaction
Jones B, et al.
Tetrahedron Letters, 57(25), 2811-2813 (2016)
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