73328
三甲基氰硅烷
technical, ≥95% (GC)
别名:
TMSCN, 氰化三甲基硅烷
等级
technical
方案
≥95% (GC)
表单
liquid
折射率
n20/D 1.392 (lit.)
沸点
114-117 °C (lit.)
mp
8-11 °C (lit.)
密度
0.793 g/mL at 20 °C (lit.)
SMILES字符串
C[Si](C)(C)C#N
InChI
1S/C4H9NSi/c1-6(2,3)4-5/h1-3H3
InChI key
LEIMLDGFXIOXMT-UHFFFAOYSA-N
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应用
Trimethylsilyl cyanide (TMSCN) can be used as a reagent in the:
- Cyanosilylation of carbonyl compounds using various catalysts.
- Synthesis of α-aminonitriles by one-pot, three-component Strecker reaction of ketones with various amines using Brønsted acid catalyst.
- Cyanation of aryl halides using palladium-complex as a catalyst.
警示用语：
Danger
危险分类
Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Flam. Liq. 2
补充剂危害
储存分类代码
3 - Flammable liquids
WGK
WGK 3
闪点(°F)
33.8 °F - closed cup
闪点(°C)
1 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
Indium tribromide: a highly effective catalyst for the addition of trimethylsilyl cyanide to ?-hetero-substituted ketones
Bandini M, et al.
Tetrahedron Letters, 42(16), 3041-3043 (2001)
Asymmetric addition of trimethylsilyl cyanide to ketones catalyzed by Al (salen)/triphenylphosphine oxide
Kim SS and Kwak Ju M
Tetrahedron, 62(1), 49-53 (2006)
A convenient and efficient procedure for the palladium-catalyzed cyanation of aryl halides using trimethylsilylcyanide
Sundermeier M, et al.
Journal of Organometallic Chemistry, 684(1-2), 50-55 (2003)
Ying-Chuan Qin et al.
Organic letters, 7(12), 2381-2383 (2005-06-04)
[reaction: see text] An efficient one-step synthesis of the optically active bifunctional BINOL ligand (S)-3 has been developed. It was found that (S)-3 in combination with Me2AlCl is a highly enantioselective catalyst for the addition of TMSCN to aliphatic aldehydes
Dinuclear {(salen)Al} complexes display expanded scope in the conjugate cyanation of alpha,beta-unsaturated imides.
Clément Mazet et al.
Angewandte Chemie (International ed. in English), 47(9), 1762-1765 (2008-01-26)
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