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742600

Difluoromethyl phenyl sulfone

≥97%

别名:

PhSO2CF2H, [(Difluoromethyl)sulfonyl]benzene

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关于此项目

经验公式（希尔记法）:
C7H6F2O2S
化学文摘社编号:
1535-65-5
分子量:
192.18
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
329765583
MDL number:
MFCD01050170
Beilstein/REAXYS Number:
2259218
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Quality Level

100

assay

≥97%

form

solid

functional group

fluoro, sulfone

SMILES string

FC(F)S(=O)(=O)c1ccccc1

InChI

1S/C7H6F2O2S/c8-7(9)12(10,11)6-4-2-1-3-5-6/h1-5,7H

InChI key

LRHDNAVPELLXDL-UHFFFAOYSA-N

Application

Reagent Used for
  • Reductive silylation and the preparation of trifluoro- and difluoromethylsilanes by reductive coupling of fluoromethyl sulfones, sulfoxides and sulfides with chlorosilanes
  • Fluoroalkylation/chloroalkylation of α,β-enones, arynes, acetylenic ketones and other Michael acceptors
  • Difluoromethylation of primary alkyl halides via nucleophilic substitution-reductive desulfonylation

Reagent used in Preparation of
  • α-difluoromethyl amines via stereoselective (phenylsulfonyl)difluoromethylation of chiral sulfinyl aldimines
  • Anti-difluoropropanediols via potassium tert-butoxide-catalyzed difluoromethylenation of aldehydes
  • β-difluoromethylated and β-difluoromethylenated alcohols and amines by regioselective nucleophilic difluoromethylation of 1,2-cyclic sulfates and sulfamidates
  • Difluoroalkenes from alkyl halides via nucleophilic substitution-elimination
  • Difluoromethyl alcohol derivatives from enolizable and non-enolizable carbonyl compounds using nucleophilic phenylsulfonyldifluoromethylation-reductive desulfonylation strategy
  • Fluoromethylated vicinal ethylenediamines via fluoromethylation of chiral α-aminobutanesulfinimines with (phenylsulfonyl)fluoromethanes followed by reductive desulfonylation and alcoholysis

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

264.0 °F

flash_point_c

128.9 °C

法规信息

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分析证书(COA)

Lot/Batch Number
BCCL4625
BCBV3416
BCBP3732V
BCBM7735V
BCBL8704V

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相关内容

Hu Group – Prof. Product Portal

Prof. Jinbo Hu's lab focuses on developing new fluorination reagents and reactions, including difluoromethylation and monofluoromethylation.

Facile synthesis of chiral alpha-difluoromethyl amines from N-(tert-butylsulfinyl)aldimines.
Ya Li et al.
Angewandte Chemie (International ed. in English), 44(36), 5882-5886 (2005-09-09)
G K Surya Prakash et al.
Organic letters, 6(23), 4315-4317 (2004-11-05)
A facile and efficient nucleophilic difluoromethylation of primary alkyl halides has been disclosed through a novel nucleophilic substitution-reductive desulfonylation strategy, using difluoromethyl phenyl sulfone as a difluoromethyl anion ("CF(2)H(-)") equivalent.
Convenient synthesis of difluoromethyl alcohols from both enolizable and non-enolizable carbonyl compounds with difluoromethyl phenyl sulfone
Prakash, G. K. S.; et al.
European Journal of Organic Chemistry, 11, 2218-2223 (2005)
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全球贸易项目编号

货号GTIN
742600-1G04061826653531
742600-10G04061833339046