描述
hydroxyl surface groups
表单
solid
分子量
PEG average Mn 6,000 (n~130; esterified with 16 OH groups)
average Mn 9,500
特点
generation 4
表面基团编号
32
转变温度
Tm 42-48 °C
官能团
hydroxyl
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一般描述
Dendrimers with Poly(ethylene) glycol (PEG) core are widely used in drug delivery systems. These dendrimers are end functionalized with hydroxyl groups which increas its biocompatibility. PEG is used as the core since it is non-toxic, non-immunogenic with favorable pharmacokinetic and tissue distribution. They are also soluble in aqueous and many organic solvents.†††
特点和优势
Well-defined structure, high intrinsic drug loading capability, flexibility for tailored functionalization.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
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Pharmaceutical and biomedical potential of PEGylated dendrimers.
Gajbhiye, V., Vijayaraj Kumar, P., Kumar Tekade, R., & Jain, N. K.
Current Pharmaceutical Design, 13(4), 415-429 (2007)
Chiara Clementi et al.
Molecular pharmaceutics, 8(4), 1063-1072 (2011-05-26)
Poly(ethylene glycol) (PEG) is the most popular polymer for protein conjugation, but its potential as carrier of low molecular weight drugs has been limited by the intrinsic low loading, owing to its chemical structure. In fact, only the two end
Marco D Giles et al.
Journal of the American Chemical Society, 130(44), 14430-14431 (2008-10-14)
At neutral pH, dendronized deep-cavity cavitands were shown to form supramolecular nanocapsules via assembly around a range of guest molecules.
Omayra L Padilla De Jesús et al.
Bioconjugate chemistry, 13(3), 453-461 (2002-05-16)
High molecular weight polymers (> 20 000 Da) have been widely used as soluble drug carriers to improve drug targeting and therapeutic efficacy. Dendritic polymers are exceptional candidates for the preparation of near monodisperse drug carriers due to their well-defined
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