764213
生物素-PEG4-炔
for copper catalyzed click labeling
别名:
乙炔-PEG4-生物素结合物
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关于此项目
经验公式（希尔记法）:
C21H35N3O6S
化学文摘社编号:
分子量:
457.58
MDL number:
UNSPSC Code:
12161502
PubChem Substance ID:
NACRES:
NA.22
产品名称
生物素-PEG4-炔, for copper catalyzed click labeling
SMILES string
O=C(NCCOCCOCCOCCOCC#C)CCCC[C@@H](SC1)[C@@]2([H])[C@]1([H])NC(N2)=O
InChI
1S/C21H35N3O6S/c1-2-8-27-10-12-29-14-15-30-13-11-28-9-7-22-19(25)6-4-3-5-18-20-17(16-31-18)23-21(26)24-20/h1,17-18,20H,3-16H2,(H,22,25)(H2,23,24,26)/t17-,18-,20-/m1/s1
InChI key
SKMJWNZZFUDLKQ-QWFCFKBJSA-N
assay
95%
form
solid
reaction suitability
reaction type: click chemistry
mp
55-64 °C
storage temp.
−20°C
Quality Level
Application
生物素-PEG4-炔可以通过生物正交叠氮-炔加成反应对 4-叠氮苯丙氨酸 (AzPhe) 丝素蛋白进行改性，以制备光敏性蛋白质材料。
生物素化试剂，采用铜催化的 1，3 偶极环加成点击化学标记含炔烃的分子或生物分子。炔烃基团与叠氮化物反应形成稳定的三唑键，有助于将生物素引入目标炔烃改性体系。
凭借Synple 全自动合成平台（SYNPLE-SC002）自动标记您的生物素
凭借Synple 全自动合成平台（SYNPLE-SC002）自动标记您的生物素
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Detection of O-GlcNAc modifications on cardiac myofilament proteins.
Ramirez-Correa GA, et al.
Heart Proteomics, 1005, 157-168 (2013)
Anthony P Silvestri et al.
Angewandte Chemie (International ed. in English), 56(35), 10438-10442 (2017-07-08)
Copper-mediated coupling between alkynes to generate a structurally rigid, linear 1,3-diyne linkage has been known for over a century. However, the mechanistic requirement to simultaneously maintain CuI and an oxidant has limited its practical utility, especially for complex functional molecules
Bibudha Parasar et al.
ACS central science, 5(5), 867-873 (2019-05-30)
The metagenome of the gut microbiome encodes tremendous potential for biosynthesizing and transforming small-molecule metabolites through the activities of enzymes expressed by intestinal bacteria. Accordingly, elucidating this metabolic network is critical for understanding how the gut microbiota contributes to health
Quantitation of Protein Translation Rate In Vivo with Bioorthogonal Click-Chemistry.
Belda-Palazon B, et al.
Proteostasis, 1449, 369-382 (2016)
Anna Rutkowska et al.
ACS chemical biology, 11(9), 2541-2550 (2016-07-08)
Late stage failures of candidate drug molecules are frequently caused by off-target effects or inefficient target engagement in vivo. In order to address these fundamental challenges in drug discovery, we developed a modular probe strategy based on bioorthogonal chemistry that
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