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Merck
CN

764833

Sigma-Aldrich

Poly(lactide-co-caprolactone)-block-poly(ethylene glycol)-block-poly(lactide-co-caprolactone)

average Mn 5700-4600-5700

别名:

PLCL-PEG-PLCL

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关于此项目

UNSPSC代码:
12162002
NACRES:
NA.23
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表单

pellets

投料比

lactide 50:50

分子量

PEG average Mn 5,000 (DCM, PEO)
PLCL average Mn 5,700
average Mn (1,000-10,000-1,000)

降解时间线

1-2 months

转变温度

Tm 34-41 °C

PDI

<1.2
<1.3 (typical PEG; overall PDI <1.8 (THF, PEO))

储存温度

2-8°C

一般描述

It belongs to the family of synthetic biodegradable polymers. It exihibits excellent tissue compatibility. PLCL-PEG-PLCL polymers are studies extensively for its drug delivery capability (both hydrophobic and hydrophilic drugs).

应用

1. Drug delivery
2. Ligament-bone interface mimicking

储存分类代码

11 - Combustible Solids

WGK

WGK 3

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Biodegradable polyester based nanoparticle formation
Material Matters, 7(3) (2012)
Bret D Ulery et al.
Journal of polymer science. Part B, Polymer physics, 49(12), 832-864 (2011-07-20)
Utilization of polymers as biomaterials has greatly impacted the advancement of modern medicine. Specifically, polymeric biomaterials that are biodegradable provide the significant advantage of being able to be broken down and removed after they have served their function. Applications are

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Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

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