771139
(E)-N-(2-Aminoethyl)-4-{2-[4-(3-azidopropoxy)phenyl]diazenyl}benzamide hydrochloride
表单
solid
反应适用性
reaction type: click chemistry
reagent type: cross-linking reagent
mp
350-355 °C
储存温度
2-8°C
SMILES字符串
NCCNC(C1=CC=C(C=C1)/N=N/C2=CC=C(OCCCN=[N+]=[N-])C=C2)=O.[H]Cl
InChI
1S/C18H21N7O2.ClH/c19-10-12-21-18(26)14-2-4-15(5-3-14)23-24-16-6-8-17(9-7-16)27-13-1-11-22-25-20;/h2-9H,1,10-13,19H2,(H,21,26);1H/b24-23+;
InChI key
UWCLSDSCVCQZQA-XMXXDQCKSA-N
应用
Azobenzene cleavable linker. Treatment with sodium dithionite (sodium hydrosulfite) reduces azo functionality, cleaving the N-N bond to yield two primary amines.
Has been used in proteomic and affinity chromatography applications. The free primary amine can be linked to any carboxylic acid containing compound or biomolecule via standard amide bond forming procedures.The azide can be reacted with a terminal alkyne or cyclooctyne derivative via the 1,3 dipolar cycloaddition click chemistry reaction.
Has been used in proteomic and affinity chromatography applications. The free primary amine can be linked to any carboxylic acid containing compound or biomolecule via standard amide bond forming procedures.The azide can be reacted with a terminal alkyne or cyclooctyne derivative via the 1,3 dipolar cycloaddition click chemistry reaction.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
A mild chemically cleavable linker system for functional proteomic applications.
Steven H L Verhelst et al.
Angewandte Chemie (International ed. in English), 46(8), 1284-1286 (2007-01-06)
Felicetta Landi et al.
Organic & biomolecular chemistry, 8(1), 56-59 (2009-12-22)
A new chemically-cleavable linker has been synthesised for the affinity-independent elution of biomolecules by classical affinity chromatography. This azo-based linker is shown to couple efficiently with "click" derivatised ligands such as biotin propargyl amide through a copper(I)-catalysed Huisgen 1,3-dipolar cycloaddition
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