77440
非那西丁
≥98.0% (HPLC)
别名:
N-(4-乙氧苯基)乙酰胺, 乙酰乙氧基苯胺, 乙酰对氨基苯乙醚, 对乙氧基乙酰苯胺, 对乙酰乙氧基苯胺
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关于此项目
线性分子式:
CH3CONHC6H4OC2H5
化学文摘社编号:
分子量:
179.22
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-533-0
Beilstein/REAXYS Number:
1869238
MDL number:
Assay:
≥98.0% (HPLC)
Form:
crystals
InChI key
CPJSUEIXXCENMM-UHFFFAOYSA-N
InChI
1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)
SMILES string
CCOc1ccc(NC(C)=O)cc1
assay
≥98.0% (HPLC)
form
crystals
mp
134-137 °C
functional group
amide
Quality Level
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Application
非那西丁 (phen) 可与四氰基乙烯 (TCNE) 在二氯甲烷中反应合成电荷转移 (CT) 配合物 [ (phen) (TCNE) 12 。
Biochem/physiol Actions
CYP1A2 和 CYP2D6 的底物。
signalword
Danger
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Muta. 2 - Skin Sens. 1 - Water-react. 2
存储类别
4.3 - Hazardous materials which set free flammable gases upon contact with water
法规信息
涉药品监管产品
此项目有
Spectroscopic investigation of the novel charge-transfer complex [(phen)(TCNE)12] formed in the reaction of phenacetin with tetracyanoethylene.
AlQaradawi SY and Nour EM
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 62(1-3), 578-581 (2005)
S P Clissold
Drugs, 32 Suppl 4, 46-59 (1986-01-01)
Since their synthesis in the late 1800s paracetamol (acetaminophen) and phenacetin have followed divergent pathways with regard to their popularity as mild analgesic/antipyretic drugs. Initially, paracetamol was discarded in favour of phenacetin because the latter drug was supposedly less toxic.
[Phenacetin abuse I. Occurrence, per capita consumption and costs of treatment].
M J Mihatsch et al.
Schweizerische medizinische Wochenschrift, 110(4), 108-115 (1980-01-28)
J A Hinson
Environmental health perspectives, 49, 71-79 (1983-03-01)
Phenacetin can be metabolized to reactive metabolites by a variety of mechanisms. (1) Phenacetin can be N-hydroxylated, and the resulting N-hydroxyphenacetin can be sulfated or glucuronidated. Whereas phenacetin N-O sulfate immediately rearranges to form a reactive metabolite which may covalently
Eslam Nouri-Nigjeh et al.
The Analyst, 136(23), 5064-5067 (2011-10-11)
Electrochemistry in combination with mass spectrometry is emerging as a versatile analytical technique in the imitation of oxidative drug metabolism during the early stages of drug discovery and development. Here, we present electrochemical O-dealkylation of phenacetin to acetaminophen by square-wave
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